溺海肺损伤的发病机制和治疗的研究进展  

Progress in pathogenesis and treatment of acute lung injury induced by seawater drowning

作　　者：王关嵩[1] 张志远[1] 钱桂生[1] 

机构地区：[1]解放军第三军医大学附属新桥医院全军呼吸内科研究所,重庆400037

出　　处：《中国急救医学》2008年第3期262-266,共5页Chinese Journal of Critical Care Medicine

基　　金：全军"十一五"重点攻关课题资助项目(No06G083);重庆市自然科学基金资助项目(No200703281434)

摘　　要：溺海肺损伤的发病机制包括低氧血症和酸碱失衡、电解质紊乱、肺泡上皮细胞和肺微血管内皮细胞的直接损伤及水通道和离子通道改变、血流动力学和心功能改变、肺组织中内皮素、降钙素和血红素氧合酶改变、肺泡巨噬细胞和表面活性物质改变、血浆氧自由基、肿瘤坏死因子和白细胞介素-8等细胞因子改变。溺海肺损伤的治疗包括机械通气、糖皮质激素、高压氧治疗、NO吸入、肺灌洗和药物治疗。Progress in pathogenesis and treatment of acute lung injury induced by seawater drowning （ SD -ALI） is reviewed. The pathogenesis of SD - ALI is including the hypoxemia, acid - base disturbance, and electrolyte disturbance in animal models, the direct damages of alveolar epithelial cells and lung microvascular endntheIial cells or the changes of water channel and ion channels in these cells, and the change of hemodynamics and heart function in animal models, alveolar macrophages and surface active substance, endothelin, calcitonin and heme oxygenase in lung tissues, oxygen free radicals, tumor necrosis factor and interleukin- 8 in plasma. The treatment of SD -ALI is involved in mechanical ventilation, glucocorticoid hormone, nitric oxide, hyperbaric oxygenation, lung perfusion, and some drugs.

关 键 词：溺海肺损伤 发病机制 治疗 

分 类 号：R649.3[医药卫生—外科学]