三苯基锡壳聚糖黄原酸酯的合成、表征及其杀螺活性研究  

Synthesis, Characterization and Molluscicidal Activity of Triphenyltin Chitosan Xanthogenate

作　　者：曹佐英[1] 许海峰[1] 唐瑞仁[2] 魏望远[3] 许外[1] 

机构地区：[1]湖南理工学院化学化工系,岳阳414000 [2]中南大学化学化工学院,长沙410083 [3]湖南省血吸虫病防治所,岳阳414000

出　　处：《无机化学学报》2008年第3期474-478,共5页Chinese Journal of Inorganic Chemistry

基　　金：湖南省自然科学基金资助项目(No.06JJ20003)

摘　　要：壳聚糖（chitosan,简称CTS）是由β（1～4）键合的D-葡糖胺残基和数目不同排列无规的N-乙酰基葡糖胺残基组成的线性多糖,是生物界中大量存在的唯一的一种碱性多糖。由于壳聚糖具有良好的生物相容性、生物可降解性和抗菌性,所以在医药、食品、化妆品、环保及生物医用材料等领域有着很好的应用前景[1～4]。自从Brown首次发现三苯基锡乙酸盐具有抗癌活性以来,有机锡化合物的研究引起了人们的极大兴趣,Dithiocarbamate-modified chitosan （chitosan xanthogenate, DTC-CTS） was synthesized by reaction of chitosan with CS2 in the presence of NaOH. The substitution degree for DTC-CTS is shown by elemental analysis to be 0.74. Triphenyltin chitosan xanthogenate （DTC-CTS-SnPh3）, （Ph3SnS2CNHC6H9O4）n, were further prepared by the nucleophilic substitution reaction of chitosan xanthogenate with triphenyltin chloride in the presence of anhydrous methanol. These compounds were characterized by UV, IR, TG-DTA and X-ray diffraction methods etc. The experiments of molluscicidal activity show that the oncomelania death rate is 100% when the concentration of the DTC-CTS-SnPh3 reaches above 0.500 0 mg·L^-1 and the soaking time is 72 h.

关 键 词：三苯基锡 壳聚糖黄原酸酯 合成 表征 杀钉螺活性 

分 类 号：O614.43[理学—无机化学] O634.4[理学—化学]