Serum α_1-acid glycoprotein,sialic　acid,and　 protein　binding　of　disopyramide　in　normal　subjects　and　cardiac　patients  

作　　者：初建设[1] 岸野吏志[1] 野村宪和 宫崎胜已 

机构地区：[1]北海道大学医学院附属医院药剂部

出　　处：《中国药理学报》1997年第5期408-410,共3页Acta Pharmacologica Sinica

摘　　要：目的：研究日本人充血性心力衰竭（ＣＨＦ）和急性心肌梗塞（ＡＭＩ）病人对血清α１酸性糖蛋白（ＡＧＰ）、唾液酸（ＳＡ）浓度及ＡＧＰ与丙吡胺（Ｄｉｓ）结合的影响．方法：对正常人、ＣＨＦ及ＡＭＩ患者血清样本９７例，采用免疫化学法测定ＡＧＰ浓度，高效液相层析法测定ＳＡ浓度及超滤膜技术和高效液相层析法测定Ｄｉｓ的体外游离浓度．结果：ＣＨＦ及ＡＭＩ患者血清ＡＧＰ浓度较正常人升高．Ｄｉｓ药物游离浓度降低．血清ＳＡ浓度的变化与血清ＡＧＰ浓度的变化趋势一致．结论：ＣＨＦ和ＡＭＩ病人血清药物游离浓度受血清ＡＧＰ结合的影响而变化，应进行临床监测．AIM: To study influence of congestive heart failure (CHF) and acute myocardial infarction (AMI) on α 1 acid glycoprotein (AGP) and sialic acid (SA) concentration, and binding of AGP to disopyramide (Dis). METHODS: Sera from 85 healthy subjects, 6 patients with CHF, and 6 patients with AMI were determined by immunochemistry for AGP, by HPLC method for sialic acid (SA), and by ultrafiltration and HPLC for the free fraction of Dis. RESULTS: Serum AGP concentrations (g·L -1 ) were 0 74±0 16 (healthy), 1 18±0 40 (d 1, CHF) and 0 90±0 24 (d 14, CHF), 1 53±0 26 (d 5, AMI) and 1 08 ( d 14, AMI ). The free Dis were 1 76±0 62 (d 1) and 2 14±0 48 (d 14), in CHF patients, 1 66±0 52 (d 5) and 1 77 (d 14) in AMI patients. The changes of serum SA and AGP concentrations showed the same tendency. CONCLUSION: The free Dis in serum was affected by the change of AGP binding in CHF and AMI patients.

关 键 词：糖蛋白 心脏病 丙吡胺 唾液酸 蛋白结合率 

分 类 号：R541.02[医药卫生—心血管疾病]