Stimulation　of　locus　coeruleus　increases　arterial　pressure　in　rabbits  

作　　者：陈永跃[1] 黄仲荪[1] 

机构地区：[1]重庆医科大学生理教研室

出　　处：《中国药理学报》1997年第5期437-440,共4页Acta Pharmacologica Sinica

摘　　要：目的：研究电刺激和化学刺激兔蓝斑（ＬＣ）对动脉血压（ＡＰ）和肾交感神经传出活动（ＲＳＡ）的影响．方法：电刺激ＬＣ，ＬＣ微量注射ＬＧｌｕ、盐酸吗啡、ＧＡＢＡ、电解毁损ＬＣ，记录ＡＰ和ＲＳＡ．结果：电刺激ＬＣ和ＬＣ注射ＬＧｌｕ均引起ＡＰ升高（分别为１３５±０３ｖｓ１９５±０８ｋＰａ和１３８±０４ｖｓ１７５±０８ｋＰａ）和ＲＳＡ增加．ＬＣ注射吗啡、ＧＡＢＡ对ＡＰ和ＲＳＡ无明显影响．电解毁损ＬＣ后电刺激ＬＣ区、ＬＣ区注射ＬＧｌｕ对ＡＰ和ＲＳＡ无明显影响．结论：兔ＬＣ兴奋引起ＡＰ升高和ＲＳＡ增加，但ＬＣ不是ＡＰ和ＲＳＡ的紧张性中枢．AIM: To study the effect of electric and chemical stimulation of locus coeruleus (LC) on arterial pressure and renal sympathetic nerve discharge activity (RSA). METHODS: Electric stimulation of LC and microinjection of L glutamate ( L Glu), morphine, and GABA into the LC of rabbits were made. The LC was destructed electrolytically. Arterial pressure and RSA were recorded. RESULTS: Both electric stimulation (150 μA, 50 Hz) of the LC and microinjection of L Glu (0 5 μmol) into unilateral LC elicited increases in arterial pressure (13 5±0 3 vs 19 5±0 8 kPa, P <0 01 and 13 8±0 4 vs 17 5±0 8 kPa, P <0 01, respectively) and RSA (by 107±14 %, P <0 01, and 88±21 %, P <0 01, respectively). Microinjection of morphine or GABA did not induce any significant changes in the above two parameters. Electrolytic lesion of the LC eliminated the pressor response induced by microinjection of L Glu. CONCLUSION: Excitation of LC has a pressor effect in rabbits, but LC is not a crucial nucleus in tonic regulation of blood pressure.

关 键 词：蓝斑 动脉血压升高 

分 类 号：R331.32[医药卫生—人体生理学]