Dextromethorphan　metabolic　phenotyping　in　a　Chinese　population  

作　　者：蔡卫民[1] 陈冰[1] 刘玉秀[1] 初晓 

机构地区：[1]南京军区南京总医院临床药理科

出　　处：《中国药理学报》1997年第5期441-444,共4页Acta Pharmacologica Sinica

摘　　要：目的：建立中国人右美沙芬（ＤＭ）氧化代谢多态性的表型分型．方法：１２０名无血缘关系的中国人口服ＤＭ２０ｍｇ后，测定其尿中ＤＭ及其代谢物右啡烷（ＤＸ）浓度，并计算代谢比值（ＭＲ）．结果：氧化代谢缺陷率为０８％（１人）；快代谢者可明显区分为极快代谢者（７６人）和中速代谢者（４３人）．０－８ｈ内ＤＭ和ＤＸ的尿排百分率分别为０４％±ｓ０５％和２６％±ｓ１３％，但两者无性别差异．结论：右美沙芬代谢的表型分型为中国人异喹胍４位羟化（ＣＹＰ２Ｄ６）多态性提供了新的信息．AIM: To establish a phenotyping of dextromethorphan (DM) oxidation polymorphism in a native Chinese population. METHODS: The urine concentrations of DM and its metabolite dextrophan (DX) were assayed by HPLC and metabolic ratios (MR) were calculated in 120 unrelated native Chinese subjects after ingestion of DM 20 mg. RESULTS: The incidence of poor metabolizers was 0 8 % (one in 120 subjects). There were distinct dimodal distributions which divided extensive metabolizers into 43 intermediate metabolizers and 76 very extensive metabolizers. The 0-8 h urinary recoveries of DM and DX were 0 4 %± s 0 5 % and 26 %± s 13 %, respectively. There was no difference in 0-8 h urinary recoveries between male and female subjects. CONCLUSION: DM metabolic phenotyping provides a new information for debrisoquine 4 hydroxylation (CYP2D6) polymorphism in native Chinese.

关 键 词：右美沙芬 多态性 显型 遗传药理学 

分 类 号：R974.2[医药卫生—药品]