氧化型染发剂的SOS/Umu试验  

Application of SOS/Umu Assay for Detection of Oxidized Hairdyes

作　　者：杨薇[1] 戴修道[1] 周德灏[1] 浦跃朴[2] 张徐军[2] 

机构地区：[1]上海医科大学公共卫生学院 [2]南京铁道医学院预防医学系

出　　处：《中国公共卫生学报》1997年第5期293-294,共2页

摘　　要：采用ＳＯＳ／Ｕｍｕ试验，对目前国内市场产销量大、成分有代表性的４种氧化型染发剂的遗传毒性进行了观察。结果表明，４种氧化型染发剂均有致遗传毒性作用。在不加Ｓ９活化系统的条件下，４种氧化型染发剂在９．８～３１２．５μｇ／管的剂量范围内，可使ＴＡ１５３５／ＰＳＫ１００２菌株产生β半乳糖苷酶的量增加，并有明显的剂量反应关系；而加Ｓ９活化系统后，未显示出遗传毒性。The genotoxicity of 4 China made oxidized hairdyes was detected with SOS/Umu assay.Hairdyes were diluted at different concentrations by water(37℃).The results showed that 4 oxidized hairdyes in test generally induced significant SOS response to TA1535/PSK1002 strain and exhibit obvious dose response relationship(r F=0.994,P<0.01;r G=0.932,P<0.01;r S=0.988,P<0.01;r X=0.987,P<0.01).All of them had not show genotoxicity with liver microsomal metabolic activation.It indicated that oxidized hairdyes had direct mutagenesis.

关 键 词：氧化型 染发剂 SOS/Umu试验 遗传毒性 

分 类 号：R996[医药卫生—毒理学] R992[医药卫生—药学]