活血颗粒对大鼠肢体缺血再灌注损伤的保护作用  

The Protection of Huoxue Grainula to Ischemical Reperfusion Injury of Rat's Limb

作　　者：李新霞[1] 孙雪生[1] 朱涛[1] 张世华[2] 

机构地区：[1]山东省莱芜市人民医院,莱芜271100 [2]山东中医药大学附属医院,济南250355

出　　处：《江西中医学院学报》2008年第1期68-70,共3页Journal of Jiangxi College of Traditional Chinese Medicine

摘　　要：目的:探讨大鼠肢体缺血再灌注损伤前后微循环变化及活血颗粒的保护作用。方法:40只大鼠肢体缺血再灌注损伤,随机分成2组。治疗组与对照组分别在再灌注后灌服活血颗粒,一天3次,连续服用7天,观测微循环的变化。结果:对照组:血流缓慢、红细胞严重聚集、大量白细胞附壁和白色微栓形成,无复流现象严重;治疗组经活血颗粒保护,微循环障碍轻,肌肉等软组织损伤轻,功能恢复满意。结论:活血颗粒对肢体缺血再灌注损伤有保护作用。Objective：To evaluate the changes of microcirculation on ischmia reperfusion injury of extremities and the pyotective effects of Huoxue grainula. Methods：40 wister mice were devided into two groups. Huoxue pellet was applicated in experimental group instead of saline in control group after ischemia and reperfusion. The changes of microcirculation were observed. Results：After 4 hours ischemia and 2 hours reperfusion of limb in control group： blood flow slowed down. Serious no-flow phenomenon, erythrocyte aggraga- tion, large amounts of neutrophil-endothelial adhesion and white microthrombosts were observed in microcirculation, in experimental group： Microcirculation disturbances were alleviated. Conclusion：Huoxuepellet could alleviate ischemia reperfusion iniury of extremities by improving microcirculation.

关 键 词：缺血再灌注损伤 活血颗粒 微循环 

分 类 号：R285.5[医药卫生—中药学]