丝裂原激活蛋白激酶信号通路在氯痤疮形成中的作用  

Role of mitogen-activated protein kinase pathway in chloracne

作　　者：张春梅[1] 汤乃军[1] 董丽[2] 赵力军[1] 马世伟[1] 魏文国[3] 张万起[1] 张芃[4] 韩伟[4] 

机构地区：[1]天津医科大学公共卫生学院劳动卫生学教研室,300070 [2]中国辐射防护研究院医用组织库 [3]天津市第一中心医院皮肤科 [4]天津市塘沽区大华医院

出　　处：《中华劳动卫生职业病杂志》2008年第3期154-156,F0003,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金资助项目（30471440）

摘　　要：目的研究丝裂原激活蛋白激酶（mitogen-activated protein kinase，MAPK）信号转导通路在氯痤疮形成中的作用，以探讨氯痤疮的发病机制。方法取患有氯痤疮的男性工人患处皮肤组织活检标本作为生物标本，采用免疫组织化学分析方法，检测氯痤疮患者皮损处和对照人群相应部位皮肤组织中磷酸化表皮生长因子受体（phosphorylated epidermal growth factor receptor，p-EGFR）和磷酸化MAPK（p-MAPK）蛋白表达水平。结果氯痤疮组全部患者中p-EGFR和p-MAPK均呈阳性表达，p-EGFR主要分布在细胞膜和细胞质，尤以细胞膜附近最明显；p-MAPK的阳性信号主要呈核浆型。对照组中全为阴性。结论氯痤疮患者皮肤组织中EGFR和MAPK发生磷酸化被激活，提示MAPK信号转导途径可能是氯痤疮的重要分子机制。Objective To investigate the role of mitogen-activated protein kinase （MAPK） signaltransduction pathway in chloracne. Methods Immunohistochemical technique was used to detect the expression of phosphorylated epidermal growth factor receptor（p-EGFR） and p-MAPK proteins in the epithelium of chloracne group and control group. Results p-EGFR and p-MAPK was found in all chloracne tissues, whereas no expression of p-EGFR and p-MAPK protein was found in control group. In the skin of chloracne patients, p-EGFR was mainly distributed in the membrane and the cytoplasm, especially in the vicinity of membrane; major positive signal of p-MAPK was in core and serosity. Conclusion EGFR and MAPK phosphorylation is found in chloracne tissues. MAPK signal transduction pathway may be one important molecular mechanism of chloracne.

关 键 词：烃类 芳香 受体 表皮生长因子 有丝分裂素激活蛋白激酶类 信号传递 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]