pim-3基因的分子生物学特性及作用  

Molecular Characterization and Biological Effects of the Pim-3 Gene

作　　者：李小燕[1] 朱水山[1] 刘亮明[2] 黄缘[1] 

机构地区：[1]南昌大学第二附属医院消化内科,南昌市330006 [2]上海交通大学附属第一人民医院松江分院消化中心,上海市200000

出　　处：《医学分子生物学杂志》2008年第2期146-148,共3页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.30660066)~~

摘　　要：Pim家族是一组编码丝/苏氨酸蛋白激酶的原癌基因,由pim-1、pim-2、pim-3组成。它们在人体不同组织器官中广泛分布,对其正常生长发育、分化、成熟起重要作用。Pim-3作为Pim家族的新成员,与Pim-1、Pim-2相似能磷酸化众多特异性底物,在细胞周期和细胞凋亡进程中起重要调控作用。同时,其在成体组织中的表达上调可导致某些恶性肿瘤的发生。The Pim family is a group of oncogenes which encode the serine/threonine protein kinase. It is composed of Pim-1, Pim-2 and Pim-3. They are extensively distributed in different tissues and organs, and play important roles in the growth, development of the body and cell differentiation. Pim-3, a new member of the family, can regulate the cell cycle, apoptosis and carciongenesis by phosphorylating specific substrates. Meanwhile, the upregulation of the Pim-3 gene can lead to the occurrence of the ma- lignant tumors. This article reviews the recent advances in the research of Pim-3 gene.

关 键 词：PIM-3 基因 细胞凋亡 恶性肿瘤 

分 类 号：R349.6[医药卫生—基础医学]