鸟氨酸脱羧酶抗酶蛋白与细胞增殖抑制  

Ornithine Decarboxylase Antizyme Protein and Inhibition of Cell Proliferation

作　　者：姜立[1] 马文丽[1] 

机构地区：[1]南方医科大学基因工程研究所,广州市510515

出　　处：《医学分子生物学杂志》2008年第2期154-159,173,共7页Journal of Medical Molecular Biology

基　　金：广东省自然科学基金(No.5004737)~~

摘　　要：鸟胺酸脱羧酶抗酶(ornithine decarboxylase antizyme,OAZ)基因通过特殊的阅读框移机制翻译全长有功能的抗酶蛋白,结合并降解鸟氨酸脱羧酶,使细胞内多聚胺浓度下降,抑制细胞增殖。抗酶还能结合cyclinD1,阻滞细胞周期。此外,OAZ还能够引起肿瘤细胞逆分化。它在多种肿瘤细胞中呈低表达,对肿瘤细胞的基因治疗有重要意义。The whole functional antizymes were translated by a unique ribosomal frameshifi mechanism. Antizymes bind to ornithine decarboxylase and promote degradation of ODC by 26S proteasome. They negatively regulate polyamines and suppress the growth of cells. Also, they can arrest cell cycle via binding to cyclin D1 and promoting the ubiquitin-dependent degradation. Moreover, OAZ can reverse differentiation of tumour cells. They are weakly expressed in a variety of tumors and play important roles in the gene therapy for tumors.

关 键 词：鸟氨酸脱羧酶 鸟氨酸脱羧酶抗酶 细胞增殖 框移机制 

分 类 号：R345[医药卫生—基础医学]