肿瘤相关免疫抑制细胞与免疫逃逸机制研究进展  

Advances in tumor-associated immunosuppressive cells and mechanism of immune escape

作　　者：焦国慧[1] 杨荣存[1] 

机构地区：[1]南开大学医学院免疫学教研室,天津300071

出　　处：《癌症进展》2008年第2期147-151,共5页Oncology Progress

摘　　要：肿瘤相关树突细胞,髓系来源抑制细胞和肿瘤相关巨噬细胞等在肿瘤免疫逃逸过程中能够诱导免疫抑制反应。肿瘤源性因子可以影响其分化、功能和迁移。细胞内信号转导途径的激活可以调节细胞内代谢、细胞因子的产生和共刺激及共抑制分子的表达,由此产生免疫抑制作用。这些方面的研究将会为抗肿瘤免疫治疗提供新的策略。Tumor- associated dendritic cells （TADCs） , myeloid- derived suppressive cells （MD- SCs）, and tumor- associated macrophages （TAMs） have been found to play a critical role in inducing immunosuppression in tumor immune escape. Tumor -derived factors may affect the differentiation, function, and trafficking of these cells. The intracellular signaling pathways activated by tumor - associated factor can regulate the intracellular metabolism, production of eytokines, and expression of costimulatory and coinhibitory molecules, by which induce tumor immune suppression. Research in these fields may result in some new strategies in tumor immunotherapy, against tumors.

关 键 词：肿瘤相关树突细胞 髓系来源抑制细胞 肿瘤相关巨噬细胞 免疫逃逸 

分 类 号：R392.11[医药卫生—免疫学]