女性压力性尿失禁患者盆底组织MMP-3和Collagen Ⅲ的研究  

Study on MMP-3 and Collagen Ⅲ in Paries Anterior Vaginas for Female Stress Urinary Incontinence

作　　者：周华[1] 王漫丽[1] 王鲁文 

机构地区：[1]郑州大学第三附属医院,郑州450052

出　　处：《中国现代医生》2008年第10期1-3,共3页China Modern Doctor

摘　　要：目的探讨女性压力性尿失禁(SUI)患者盆底支持结构中MMP-3、胶原蛋白Ⅲ与SUI发生的关系。方法采用免疫组化方法,测定30例压力性尿失禁患者(SUI组)MMP-3,胶原蛋白Ⅲ,并选择同期20例妇科良性病变而行子宫切除术者作为对照(对照组),于手术中取患者阴道前壁,采用免疫组织化学方法观察MMP-3、CollagenⅢ的表达情况。结果SUI组阴道前壁组织中MMP-3表达明显高于对照组(P<0.05),Collagen Ⅲ的表达明显低于对照组(P<0.05)。结论SUI患者阴道前壁组织中胶原代谢活跃、胶原分解增加可能是SUI的发病机制之一。Objective To investigate collagen metabolism in stress urinary incontinence （SUI）so as to determine the alteration that contributes to SUI. Methods Biopsy specimens of vaginalwall tissue from 30 women with stress urinary incontinencewere collected, with matched specimens from 20 female patients without SUI. Immunohistochemical technique were applied to detect the expression of MMP-3 and Collagen Ⅲ. Results SUI group demonstrated a significant increase in MMP-3 expression and a decrease in Collagen Ⅲ expression,with significant difference with control group. Conclusion Patients with SUI were in the predominant status of collagen breakdown,which may contribute to the pathogenesis of SUI.

关 键 词：尿失禁 压力性 基质金属蛋白酶-3 胶原蛋白Ⅲ 相关性 

分 类 号：R694[医药卫生—泌尿科学]