红霉素和阿齐霉素对大鼠胃肠感觉传入的影响  

Effect of erythromycin and azithromycin on sensation afferent nerve functions of gastrointestinal tract in rats

作　　者：肖刚[1] 李静[1] 邓丽君[1] 陆杰[1] 

机构地区：[1]重庆医科大学生理教研室,重庆市400016

出　　处：《世界华人消化杂志》2008年第6期607-612,共6页World Chinese Journal of Digestology

摘　　要：目的:用电生理方法研究红霉素和阿齐霉素对胃肠感觉传入的影响.方法:64只SD成年大鼠随机分成8组(n=8):红霉素组:对照、小剂量(0.1 mg/kg)、中剂量(0.5 mg/kg)、大剂量(1mg/kg)组.阿齐霉素组:分组和剂量均与红霉素相同.经颈静脉注射生理盐水、红霉素、阿齐霉素,观察记录注药前和注药后30 min内膈下迷走神经传入自发放电和扩胃诱发放电两种状态下的变化.结果:静脉注射小剂量红霉素和阿齐霉素自发放电和对扩胃诱发放电均无显著变化,20 min后中、大剂量红霉素和阿齐霉素注药后自发放电(红霉素:8.34±0.37,8.54±0.26 vs 7.78±0.23,7.84±8.27;阿齐霉素:8.57±0.43,8.28±0.38 vs 7.74±0.21,7.86±0.30)和对扩胃诱发放电均增强(红霉素:8.54±0.34,8.61±0.20 vs 8.13±0.36,8.19±0.21;阿齐霉素:8.54±0.30,8.42±0.21 vs 8.24±0.22,8.22±0.19)与相应的对照组和小剂量组间差异有统计学意义.结论:红霉素和阿齐霉素能显著增加胃肠感觉传入.AIM：To investigate the effect of erythromycin and azithromycin on sensation afferent nerve functions of gastrointestinal tract in rats and its corresponding mechanism. METHODS：Sixty-four rats were randomly divided into erythromycin group,azithromycin group,control group,low dose group（0.1mg/ kg）,medium dose group（0.5mg/kg）and high dose group（1 mg/kg）.Spontaneous afferent nerve discharge and gastric distention-induced afferent nerve discharge of subdiaphragmatic vagus nerve were recorded half an hour before and after intravenous injection of different doses of erythromycin and azithromycinin. RESULTS：Intravenous low erythromycin and azithromycin dose had no obvious exciting effect on spontaneous afferent nerve discharge and gastric distention-induced afferent nerve discharge of subdiaphragmatic vagus nerve after 20 min.Intravenous medium and high erythromycin and azithromycin dose had obvious exciting effect on spontaneous afferent nerve discharge（erythromycin：8.34±0.37,8.54±0.26 vs 7.78±0.23,7.84±8.27;azithromycin：8.57±0.43, 8.28±0.38 vs 7.74±0.21,7.86±0.30）and gastric distention-induced afferent nerve discharge of subdiaphragmatic vagus nerve（erythromycin： 8.54±0.34,8.61±0.20 vs 8.13±0.36,8.19±0.21; azithromycin：8.54±0.30,8.42±0.21 vs 8.24±0.22, 8.22±0.19）,which was statistically significant compared with the control and low dose groups. CONCLUSION：Erythromycin and azithromycin have significant effects on sensation afferent nerve functions of gastrointestinal tract in rats.

关 键 词：红霉素 阿齐霉素 迷走神经 胃肠感觉 

分 类 号：R96[医药卫生—药理学]