蒲黄总黄酮对犬急性心肌缺血的保护作用  

Protective Effects of Total Flavones of Pollen Typhae on Acute Myocardial Ischemia Dogs

作　　者：王景祥[1] 吕文伟[2] 于静[1] 祁功才[3] 陈霞[2] 

机构地区：[1]吉林省柳河医院,吉林柳河135300 [2]吉林大学基础医学院药理学教研室,吉林长春130021 [3]吉林大学中日联谊医院,吉林长春130031

出　　处：《中国实验方剂学杂志》2008年第1期39-42,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察蒲黄总黄酮对犬急性心肌缺血的保护作用。方法:采用麻醉开胸犬结扎左冠状动脉前降支(LAD)制备急性心肌缺血模型,观察蒲黄总黄酮对心外膜电图(EECG)、心肌梗死面积(MIS)和血清酶的影响。结果:蒲黄总黄酮可减少缺血程度(∑-ST),降低缺血范围(N-ST),缩小缺血心肌的MIS,降低血清中磷酸肌酸激酶(CPK)、乳酸脱氢酶(LDH)的活性,降低血清中游离脂肪酸(FFA)、过氧化脂质(LPO)含量,提高超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性。结论:蒲黄总黄酮对实验性心肌缺血犬的心肌具有保护作用。Objective：The protective effects of total flavones of Pollen Typhae on acute myocardial ischemia were investigated in dogs. Methods： Acute myocardial ischemia model was made by ligation of left anterior descending artery in the anesthetized open chest dogs. The effects of total flavones of Pollen Typhae on epicardium electrocardiogram（EECG） and myocardial infarction square（MIS） were measured, and effects on enzymology in serm were also determined. Results： Total flavones of Pollen Typhae can reduce the degree and scope of myocardial ischemia （∑-ST and N-ST）, and decrease myocardial infarction square. Moreover, it also can reduce FFA and LPO content in serum, and improve SOD and GSH-Px activity in acute myocardial dogs. Conclusions： Total flavones of Pollen Typhae have the protective effects on acute myocardial ischemia dogs.

关 键 词：蒲黄总黄酮 心肌缺血 心外膜电图 血清酶 

分 类 号：R285.5[医药卫生—中药学]