祛白酊对实验性白癜风的治疗作用  

Therapeutic Effect of Qubai Tincture on Experimental Vitiligo

作　　者：盛国荣[1] 

机构地区：[1]江苏省南通市皮肤病性病防治所,江苏南通226006

出　　处：《中国实验方剂学杂志》2008年第2期57-59,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：南通市指令性社会发展科技计划项目(编号:S2007026)

摘　　要：目的:以新适确得为对照,考察祛白酊对豚鼠实验性白癜风的作用。方法:用化学脱色法制备白癜风动物模型,分别用祛白酊和新适确得对白癜风动物模型进行治疗,每次外涂祛白酊1.0 mL,外涂新适确得1.0 g,每日2次,均连用50 d。疗程结束后,肉眼观察药物治疗豚鼠实验性白癜风的疗效,并考察药物对豚鼠皮肤黑素形成和胆碱酯酶的影响。结果:祛白酊对白癜风动物模型有良好的治疗作用,与模型组比较有极显著性差异(P<0.01),对白癜风动物模型皮肤黑色素的影响和对胆碱酯酶的影响与模型组比较有极显著差异(P<0.01),与新适确得组比较有显著性差异(P<0.05)。结论:祛白酊对豚鼠实验性白癜风具有良好的治疗作用,为临床应用提供了实验依据。Objective： To study the effect of Qubai Tincture on experimental vitiligo of guinea pig. Methods： Animal model of vitiligo was established by chemical decolorization. The animal model of vitiligo is treated with Qubai Tincture 1.0 mL and Sicorten Plus 1.0 g 2 times a day respectively, observe the influence on the formation of skin melanin and cholinesterase after 50 days. Results. Compared with model group, Qubai Tincture has significant effect on the formation of skin melanin and cholinesterase（ P 〈 0.01 ）. Conclusions： Qubai Tincture has showed therapeutic action on the experimental vitiligo of guinea pig, and provide experimental evidence for clinical application.

关 键 词：祛白酊 白癜风 动物模型 疗效 

分 类 号：R285.5[医药卫生—中药学]