瘀毒病机与动脉粥样硬化易损斑块相关的理论思考  

Theoretical Thinking on Relationship between Toxic-stasis Pathogenicity and Atherosclerotic Vulnerable Plaque

作　　者：张京春[1] 陈可冀[1] 

机构地区：[1]中国中医科学院西苑医院心血管病中心,北京100091

出　　处：《中国中西医结合杂志》2008年第4期366-368,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(No.2006CB504803);国家中医药管理局科技项目基金课题(No.0405JP64)

摘　　要：不稳定斑块破裂是发生具有代表性的心血管血栓性疾病——急性冠脉综合征(acute coronary syndrome,ACS)的主要原因。考虑到现代医学对于易损斑块炎性反应及血栓形成的病因学认识与中医学"毒"、"瘀"之病因病机和临证特点的相似性,加之临床表征方面的毒瘀特点,讨论中医学以"瘀血"为ACS的主要病因病机的传统认识似应扩展为"瘀毒"致动脉粥样硬化(AS)易损斑块破裂从而发生ACS。认为符合循证医学的临床研究以证实相关疾病的临床表征并形成"瘀毒"病因病机的临床诊疗规范,对于易损斑块及其作为病理基础的ACS这一心血管血栓性疾病的防治将具有积极的意义。Vulnerable plaque rupture is the main cause of acute coronary syndrome （ACS）, a representative cardiovascular thrombotic disease. Considering that the Western medical pathogenetic recognition on vulnerable plaque inflammatory reaction and thrombus formation is similar to the etiopathogenesis and clinical characteristics of toxin and stasis as well as the clinical manifestation of toxic-stasis in TCM, the authors believe that it is necessary to expand the previous TCM thinking on taking blood stasis as the main etiopathogenesis for ACS to that ACS is caused by the toxic-stasis induced vulnerable plaque rupture. Therefore to make sense, depending evidence-based medical principle, the relationship between toxic-stasis and vulnerable plaque forming and rupturing, and to form the clinical norm for diagnosis and treatment of toxic-stasis should be helpful for the prevention and control of ACS.

关 键 词：瘀毒 病因病机 易损斑块 急性冠脉综合征 心血管血栓性疾病 

分 类 号：R259[医药卫生—中西医结合]