不同pH值的人工合成尿液对皮肤表面pH值的影响  

Impact of synthetic urine at different pH values on skin surface pH

作　　者：谈益妹[1] 王学民[1] 卢宝荣[2] 陈曦[2] Mauricio Odio 周玉田[1] 吴琰瑜[1] 万向红 陈聪[4] 

机构地区：[1]上海市皮肤病性病医院皮肤与化妆品研究室,200050 [2]中国制浆造纸研究院 [3]美国宝洁公司婴儿护理部 [4]中国宝洁公司

出　　处：《中华皮肤科杂志》2008年第4期244-247,共4页Chinese Journal of Dermatology

摘　　要：目的观察不同pH值的人工合成尿液对皮肤表面pH值的影响。方法分别应用pH2．0，3．5，5．0，6．5，8．0和10．0的人工合成尿液、蒸馏水和0．25％十二烷基硫酸钠水溶液对敏感性皮肤和正常皮肤行4h，20h，24h三个阶段的封闭型斑贴试验，应用临床评估、皮肤表面pH值和TEWL值来评判皮肤反应。结果敏感性皮肤和正常皮肤对各种溶液的反应相似。两种pH仪测量皮肤表面pH值排列顺序与原溶液的pH值顺序相同。不同pH值的人工合成尿液改变了皮肤表面pH值，而且这种改变在斑贴去除后24h仍然存在。各人工合成尿液的TEWL值均不高于蒸馏水。只有72hpH6．5，8．0和10．0的人工合成尿液的临床反应高于蒸馏水。结论不同pH值的人工合成尿液改变皮肤表面pH值，pH2．0-pH10．0的人工合成尿液对人体皮肤的安全性与蒸馏水相似。Objective To investigate the impact of synthetic urine （synurine solution） at different pH values on skin surface. Methods Sixty-four healthy volunteers were enrolled into this study. Based on the results of lactic acid test and questionaires, these subjects were enrolled as sensitive skin group and normal skin group. The 4-, 20-, and 24-hour occlusive patch tests were successively performed with synthetic urine at various pH values （2.0, 3.5, 5.0, 6.5, 8.0 and 10.0） on the two groups of volunteers. The distilled water and 0.25% sodium lauryl sulphate （SLS） served as control. The skin surface pH values were measured by potable pH meter before, and at 24 h, 48 h, 72 h after the first patch. Half an hour after the latter three detections of pH values, the skin response was evaluated clinically, as well as by transepidermal water loss （TEWL） and pH values, which were measured by pH-900 pH Meter. Results The responses to these solu- tions were similar between sensitive and normal skin groups. The order of skin surface pH values measured by the two pH meters was consistent with that of the original solutions. The skin surface pH value was altered by the synthetic urine, and this change was still present at 24 hours after the patches were removed. The TEWL values of skin challenged by synthetic urine were not higher than those by distilled water. The skin responses at 72 hours were more intense to the synthetic urines with pH values of 6.5, 8.0, 10.0 than to distilled water. Conclusions Synthetic urines with different pH values can alter skin surface pH values, and skin responses to synthetic urines with a pH range 2.0-10.0 are similar to those to distilled water.

关 键 词：皮肤 人工合成尿液 经表皮失水率 

分 类 号：R512.4[医药卫生—内科学] R725.97[医药卫生—临床医学]