岩白菜素的Mannich反应  

Mannich Reaction of Bergenin

作　　者：孙科[1] 王继良[1] 邹澄[1] 赵庆[2] 余琴[1] 邵曰凤[1] 张荣平[1] 

机构地区：[1]昆明医学院药学院,云南昆明650031 [2]云南中医学院中药学院,云南昆明650200

出　　处：《云南中医学院学报》2008年第2期25-27,33,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南省应用基础研究计划面上项目(NO:2006C0045M)资助

摘　　要：采用制备的仲胺与岩白菜素发生Mannich反应,得到了9个新的岩白菜素衍生物,期望从中找到生物利用度更高或者具有新活性的含氮化合物。Mannich reaction of Bergenin with secondary amines and formaldehyde were carried out and nine new nitrogen containing derivatives were prepared. Compounds with better biological availability or new biological activities were expected to obtain.

关 键 词：岩白菜素 MANNICH反应 含氮衍生物 

分 类 号：R284[医药卫生—中药学]