赤丹丸与其组方药材的体外抑菌试验  

Antibacterial activity of Chidan pill and its medicinal substances in vitro

作　　者：袁汀[1] 徐英宏[1] 菅凌燕[1] 杨君[1] 

机构地区：[1]中国医科大学附属第二医院药剂科

出　　处：《中外医疗》2008年第5期29-30,共2页China & Foreign Medical Treatment

摘　　要：目的研究赤丹丸及其组方药材的体外抑菌作用。方法采用液体培养基2倍稀释法测定赤丹丸及其组方药材的水提取物和乙醇提取物对金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌、白色念珠菌的体外最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。结果赤丹丸及其组方药材的水提取物和醇提取物对白色念珠菌的抑菌作用明显弱于对其它3种菌的作用（P〈0.05）,其中药材的水提取物体外抑制白色念珠菌作用相对较强（P〈0.05）；各种提取物对金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌的抑菌作用也各有差异。药材水提取物对铜绿假单胞菌、白色念珠菌的抑菌作用最强（P〈0.05）；赤丹丸醇提取物对金黄色葡萄球菌、大肠埃希菌的抑菌作用最强（P〈0.05）。结论赤丹丸及其组方药材的水提取物与醇提取物对金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌、白色念珠菌均具有体外抑菌作用。Objective：To investigate the antibacterial activity of Chidan pill and its medicinal substances in vitro.Methods：The minimalinhibitory concentration（MIC）and the minimal bactericidal concentration （MBC） of the aqueous and alcohol extractives of the Chidan pill andits medicinal substances against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Blastomyces albicans were determined.Results：The antibacterial activity of both aqueOus and alcohol extractives of Chidan pill and its medicinal substances against Blasto--myces albicans was weaker than that against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa in vitro. Among all kindsof extractives, the antibacterial activity of the aqueous extractive of the medicinal substances against Blastomyces albicans was relativelystronger （P〈0.05）.The antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pscudomonas aeruginosa were differentamong various kinds of extractives. The antibacterial activity of the aqueous extractive of the medicinal substances against Blastomyces albi--cans and Pseudomonas aeruginosa and the antibacterial activity of the alcohol extractive of Chidan pill against Staphylococcus aureus and Es--cherichia coli was the strongest, respectively.Conclusion：The aqueous and alcohol extractives of Chidan pill and its medicinal substanceshave antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Blastomyces albicans in vitro.

关 键 词：赤丹丸 药材 体外抑菌 

分 类 号：R285.5[医药卫生—中药学]