M受体-G蛋白信号转导途径研究进展  

Signal transduction between muscarinic receotors and G proteins: research advances

作　　者：孙科[1] 郭政东[1] 

机构地区：[1]中国医科大学药学院药物毒理学教研室,辽宁沈阳110001

出　　处：《国际药学研究杂志》2008年第2期87-91,共5页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(No.30171077);辽宁省自然科学基金资助项目(No.002039)

摘　　要：毒蕈碱乙酰胆碱受体(mAChR)是G蛋白偶联受体超家族中的一员,具有该家族特征性的结构和信号转导方式。GTP结合蛋白(G protein)是一类具有GTP酶活性的蛋白质,由α、β和γ三个亚基构成。mAChR可以与G蛋白偶联,引起GTP与α亚基结合,导致Gα与Gβγ分离。近年来发现,不但Gα-GTP可以调节效应分子,Gβγ也可以调节许多效应分子如腺苷酸环化酶、磷脂酶C、K+通道、Ca2+通道、MAPK和受体激酶等,介导一系列的生物学效应,在信号转导过程中发挥重要的作用。muscarinic acetylcholine receptor（mAChR） are members of a superfamily of receptors that couple to G-protein. G-protein, consist of α, β and γsubunits, promotes the exchang of GDP for GTP on α subunit. When bound to GTP, Gα subunit can regulate intracellular effectors. In the GDP-bound state, Gα subunit is inhibited by binding to a heterodimer composed of the β and γ subunits. Recently, evidence has accumulated showing that not only the α subunit of G proteins but also the βγsubunits target and modulate effector proteins （such as adenylate cyclase, phospholipase C, K ^＋ channels, Ca^2＋ channels, mitogen-actirated protein kinase, receptor kinase, et al. ） to regulate cellular functions.

关 键 词：受体 毒蕈碱 GTP结合蛋白 信号转导 效应分子 

分 类 号：R33[医药卫生—人体生理学]