氨基磺酸催化的Mannich反应合成β-氨基酮  

Mannich synthesis of β-aminobutanones catalyzed by sulfamic acid

作　　者：吴璇[1] 李维思[1] 李振江[1] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210009

出　　处：《化学试剂》2008年第4期277-279,共3页Chemical Reagents

基　　金：国家973计划资助项目(2003CB716004)

摘　　要：采用廉价的氨基磺酸作为催化剂,芳香酮以及环己酮、3-戊酮与芳香醛、芳香胺可直接发生Mannich反应,生成相应的Mannich碱,产率均在60%～95%。氨基磺酸作为催化剂表现出高效的催化活性,优良的稳定性及良好的利用效率。When sulfamic acid is used to catalyze the Mannich reaction of aromatic ketone （ nadone or 3-pentanone） with aromatic aldehydes and aromatic amines, the commensurate Mannich-bases can easily be obtained, and the product yield is in the range of 60% -95% .Sulfamic acid as an inexpensive solid catalyst with good stability can catalyze the reaction in high efficiency and also can be readily recycled and reused.

关 键 词：MANNICH反应 氨基磺酸 催化 

分 类 号：O625.63[理学—有机化学]