紫玉盘种子中的番荔枝内酯成分研究 Ⅰ.紫玉盘素(Microcarpacin)的分离及结构鉴定  

Studies on Annonaceous Acetogenins from Uvaria microcarpa Seeds. I. The Isolation and Structure of Microcarpacin

作　　者：陈文森[1] 姚祝军[2] 吴毓林[2] 

机构地区：[1]中国科学院华南植物研究所,广州510650 [2]中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海200032

出　　处：《化学学报》1997年第7期723-728,共6页Acta Chimica Sinica

基　　金：国家自然科学基金资助项目

摘　　要：从紫玉盘(Uvaria microcarpa Champ.ex Benth)种子中首次分离得到一个新的邻双四氢呋喃环番荔枝内酯(Annonaceous acetogenin)化合物—紫玉盘素(Microcarpacin).同时首次以纯化合物形式分离得到两个已知的番荔枝内酯NarumicinsⅠ和Narumicins Ⅱ.Microcarpacin (1) ,a new adjacent bis - tetrahydrofuranyl annonaceous acetogenin was isolated from the seeds of Uvaria microcarpa Champ, ex Benth. The structure of 1 is elucidated based on spectroscopic methods and the existence of four hydroxyls is confirmed by the acetylation of the title compound. Microcarpacin is the first example with a hydroxyl group at 33 - C among the known annonaceous acetogenins. In addition, two known 24 - C epimeric acetogenins, Narumicins I (2) and Narumicins II (3) were also isolated from the same plant source. The pure compounds 2 and 3 were obtained for the first time by careful HPLC preparation and the spectral data of the corresponding compound are also reported in this paper.

关 键 词：番荔枝内酯 紫玉盘 紫玉盘素 成分 分离 结构 

分 类 号：R931.71[医药卫生—生药学] R284.2[医药卫生—药学]