化学发光法测定盐酸洛美沙星胶囊  

Determination of Lomefloxacin Hydrochloride Capsule by Chemiluminescence

作　　者：郭玉华[1] 郁有祝[1] 周杰[2] 屈凌波[2] 

机构地区：[1]安阳工学院化学与环境工程系,河南安阳455000 [2]郑州大学化学系,郑州450052

出　　处：《河南师范大学学报（自然科学版）》2008年第2期143-144,共2页Journal of Henan Normal University(Natural Science Edition)

基　　金：2004年河南省杰出青年基金

摘　　要：在酸性条件下,盐酸洛美沙星对Ce（IV）-Na2SO3微弱化学发光体系具有很强的增敏作用,据此建立了测定盐酸洛美沙星的新方法.该方法对盐酸洛美沙星的检出限为0.005 0 mg·L^-1,线性范围是0.01-10.0 mg·L^-1,相对标准偏差（n=10,C=1.0 mg·L^-1）为1.1%,对盐酸洛美沙星的两种胶囊的测定结果较为满意,回收率在96%-106%之间.Lomefloxacin hydrochloride can greatly enhance the emission intensity of the weak chemiluminescence reaction of cerium（Ⅳ） and sulphite in acid condition. Based on this phenomenon, a new flow injection chemiluminescence method for determination of lomefloxacin hydrochloride has been developed. The linear range of this method is 0.01 - 10 mg · L^-1 lomefloxacin hydrochloride with the detection limit of 0. 005 0 mg· L^-1 and the relative standard devlation（n= 10, C= 1.0mg · L^-1 ） is 1.1%. This method has been applied to the determination of lomefloxacin hydrochloride in capsules with recovery between 96% and 106%.

关 键 词：化学发光 盐酸洛美沙星 流动注射 

分 类 号：O657.39[理学—分析化学]