七叶皂甙钠在放射性肺损伤防治中的临床观察  

PREVENTION OF ESCIN NATRIUM ON RADIATIONINDUCED PULMONARY INJURY

作　　者：房丽[1] 王红阳[1] 王慧[1] 李球兵[1] 王立民[1] 

机构地区：[1]华北煤炭医学院附属医院,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2008年第3期303-305,共3页Chinese Journal of Coal Industry Medicine

基　　金：河北省中医药管理局科研立项课题;编号:2007108

摘　　要：目的观察七叶皂甙钠预防放射性肺损伤临床疗效。方法将64例放疗肺癌患者随机分为二组:单纯放疗对照组(RT)和放疗加用七叶皂甙钠观察组(RT+Q)。根据RTOG诊断标准将放射性肺损伤分为0～4级,以≥2级者为观察指标,同时观察肺功能、影像学变化;并比较二组KPS评分。结果放射性肺损伤总发生率观察组9.38%,对照组25.00%;观察组肺功能明显改善,KPS评分优于对照组(P<0.01),未出现不良反应。结论七叶皂甙钠能有效预防严重放射性肺损伤的发生,无激素类药物不良反应;可提高患者生活质量。Objective To observe the preventive effect of escin natrium on radiation induced pulmonary injury. Methods We selected patients with lung cancer （n = 64） were divided into two groups. The control group was treated by radiotherapy （RT） and the observed group was treated by escin natrium with radiotherapy （RT ＋ Q）,starting on the first day of radiotherapy. Radiotherapy pulmonary injury graded from 0 to 4 according to RTOG. Above 2 grade pneumonitis were diagnosed, lung function and imageology＇s change were observed. The KPS＇s score was compared in all patients with above of two groups after 6 months. Results The patients were evaluated, the rate of radiation induced pneumonit is 9.38% in the RT ＋ Q group and 25.00% in the RT group, lung function and KPS＇s score were improved in RT ＋ Q group than that in RT group（P〈0.01 ）without the side effect. Conclusion Escin natrium can prevent the radiation induced pulmonary injury and improves the quality of life in patients.

关 键 词：七叶皂甙钠 放射性肺损伤 预防 

分 类 号：R818.841[医药卫生—放射医学] R651.150.5[医药卫生—临床医学]