钾通道开放剂烟酰胺对肺动脉高压血浆内皮素1影响的临床观察  

Influence of Nictinamide on endotheline in patients with pulmonary arterial hypertension

作　　者：周义乾[1] 李金兰[2] 张素荣[3] 

机构地区：[1]新乡医学院第一附属医院结核科,河南省卫辉市453100 [2]新乡医学院第一附属医院呼吸科,河南省卫辉市453100 [3]新乡医学院第一附属医院心内科,河南省卫辉市453100

出　　处：《中国综合临床》2008年第4期316-317,共2页Clinical Medicine of China

基　　金：河南省科技厅科技攻关基金资助项目（0224630057）

摘　　要：目的探讨钾通道开放剂烟酰胺对肺动脉高压患者血浆内皮素的影响。方法入选66例缺氧性肺动脉高压患者，随机分为烟酰胺治疗组（治疗组）和常规治疗组（对照组）。每组33例，测定2组肺动脉高压患者治疗前后血浆内皮素1变化。结果治疗组治疗后较治疗前血浆内皮素1明显降低（P〈0．01）。对照组治疗前后自身比较，血浆内皮素1无明显变化（P〉0．05）；治疗组与对照组治疗前后的差值比较有统计学意义（P〈0．01）。结论烟酰胺可保护内皮细胞，减少内皮素1的分泌和释放，对缺氧性肺动脉高压有治疗作用。Objective To study the influence of Nictinamide on the endotheline （ ET-1 ） in patients with pulmonary arterial hypertension （ PAH ）. Methods 66 cases of PAH were divided randomly into two groups （ n = 33 for each ） ： the Nictinamide treatment group and the control group. The changes of endotheline were compared before and after treatment. Results After treatment serum endotheline was significantly lower in the treatment group （ P 〈 0.01 ） ,but there was no difference in the control group before and after treatment（ P 〉0.05 ）. The significant difference was observed between treatment group and control group （ P 〈 0.01 ）. Conclusion Nictinamide will reduce the level of endotheline and confers some degree therapeutic and preventive value for PAH.

关 键 词：烟酰胺 肺动脉高压 内皮素1 

分 类 号：R543.2[医药卫生—心血管疾病]