2型糖尿病患者合并中心性肥胖相关因素分析  

Study on the relationship between central obesity and metabolic disturbances in patients with type 2 diabetes

作　　者：刘昕[1] 陈红[1] 武蓓[1] 任景怡[1] 

机构地区：[1]北京大学人民医院心内科,北京100044

出　　处：《中国综合临床》2008年第4期372-374,共3页Clinical Medicine of China

摘　　要：目的分析2型糖尿病（T2DM）患者合并中心性肥胖的相关因素。方法280例T2DM患者，以腰围数值（男≥90．0cm、女〉180．0cm）定义为中心性肥胖，分为中心性肥胖组和非中心性肥胖组，对其年龄、性别、吸烟史、饮酒史、冠状动脉粥样硬化性心脏病（冠心病）史、原发性高血压史、糖脂代谢指标、肝肾功能指标等进行分析，Logestic回归分析中心性肥胖与上述因素之间的关系。结果组间比较显示，中心性肥胖组原发性高血压患病率、稳态模式胰岛素抵抗指数（HOMAIR）较高，差异均有统计学意义（均P〈0．05）；男性比例低于女性，脂肪肝患病率、甘油三酯（TG）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、超敏，C-反应蛋白（hs—CRP）均较高，差异均有统计学意义（均P〈0．01）；高密度脂蛋白胆固醇（HDL-C）较低，差异有统计学意义（P〈0．01）。Logistic回归显示，在合并中心性肥胖的T2DM患者中，女性比例、脂肪肝患病率、ALT高于非中心性肥胖组，2组比较差异均有统计学意义（均P〈0．01）；hs-CRP高于非中心性肥胖组，2组比较差异有统计学意义（P〈0．05）；HDL—C低于非中心性肥胖组，2组比较差异有统计学意义（P〈0．01）。结论在12DM患者中性别、脂肪肝患病率、ALT、hs-CRP及HDL-C与中心性肥胖密切相关。Objective To assess the relationship between central obesity and metabolic disturbances in patients with type 2 diabetes mellitus （ T2DM ）. Methods Patients with T2DM were recurited in the study, who were defined as central obesity if the waist circumference was ≥90.0 cm in man or ≥80.0 cm in woman. Data （ age, sex, history of smoking and alcobole consumption ,coronary heart disease, hypertension, lipid metabolism index and liver and kidney function ） were pooled to analyze the metabolic disturbances between central obesity and non-central obesity groups. The relationship between central obesity and metabolic disturbances was analyzed by using multiple factorial logistic regression analysis. Results The patients with T2DM accompanied with central obesity had significant differences with those non-central obesity patients in sex,hypertension,fatty liver,and the levels of HOMA IR（ P 〈 0.05） ,TG,ALT,AST,hsCRP（ P 〈 0.01 for each） and HDL-C （P 〈0.01 ）. Multiple factorial logistic regression showed that individuals accompanied with central obesity were composed of more female than non-central obesity group,and they had much more fatty livers,and higher ALT （P 〈0.05 ） ,and lower HDL-C levels （ P 〈0.01 ）. Condusion Some factors such as sex,fatty livcr,ALT,hsCRP and HDL-C arc significantly associated with central obesity in type 2 diabetes mellitas patients.

关 键 词：2型糖尿病 中心性肥胖 代谢综合征 

分 类 号：R589.2[医药卫生—内分泌]