肾上腺髓质素在妊娠高血压疾病中的表达及意义  

The study of the adrenomedullin in patients with hypertensive disorder complicating pregnancy.

作　　者：陈敏秀[1] 王蕾[1] 鞠文博[2] 

机构地区：[1]首都医科大学附属北京同仁医院妇产科,北京100176 [2]威海市立医院妇产科

出　　处：《现代妇产科进展》2008年第3期169-171,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:通过对妊娠高血压疾病患者血浆及胎盘组织中肾上腺髓质素含量的测定,探讨肾上腺髓质素在妊娠高血压疾病中的变化及可能机制。方法:放射免疫分析法测定非孕妇女(30例)、妊娠高血压疾病妇女(50例)、正常晚孕妇女(30例)血浆中肾上腺髓质素的含量;放射免疫分析法测定后两组胎盘组织提取液中肾上腺髓质素含量。结果:(1)妊娠高血压疾病组血浆肾上腺髓质素含量明显高于正常晚孕组及非孕组,与正常晚孕组的差异有统计学意义(P<0.05),与非孕组的差异具有极显著的统计学意义(P<0.01),并且,随病情加重而增加,病情越重,升高越明显;(2)妊娠高血压疾病组胎盘组织中肾上腺髓质素含量明显高于正常晚孕组,差异有统计学意义(P<0.05);(3)血浆肾上腺髓质素含量、胎盘肾上腺髓质素含量与平均动脉压呈正相关(r=0.75,P<0.01;r= 0.73,P<0.01)。结论:肾上腺髓质素在妊娠高血压疾病患者中升高,它可能作为一种代偿机制参与了妊娠高血压疾病的发生。Objective： To detect the adrenomedullin （ ADM ） concentration of plasma and placenta in patients with hypertensive disorder complicating pregnancy（ HDP）, which in order to investigate the change and probable mechanism of ADM. Methods：Thirty normal non-pregnancy（NNP） ,fifty hypertensive disorder complicating pregnancy and thirty normal later trimester pregnancy（NLP） were selected as subjects. The ADM concentration of plasma and placenta were detected by radioimmunoassay. Results： （ 1 ） Compared with control group, the plasma ADM concentration in HDP was significantly increased. There were significantly difference among HDP, NLPand NNP. The more severe the diseases, the higher the concentration were, and which increase with the severity of HDP; （2） The placenta ADM concentration in HDP was significantly higher than that of normal later trimester pregnancy;there was significantly difference between HDP and NLP; （ 3 ） The ADM concentration of plasma and placenta were positively correlated with MAP. Conclusion：The ADM concentration of plasma and placenta are higher in HDP,which may play a role in the pathogenesis of hypertensive disorder complicating pregnancy as a compensative mechanism.

关 键 词：肾上腺髓质素 妊娠高血压疾病 血浆 胎盘 

分 类 号：R714.246[医药卫生—妇产科学]