地诺前列酮用于足月妊娠羊水偏少病例引产的临床研究  

A clinical study on the effects of dinoprostone for induction of oligohydraminios pregnancies in term.

作　　者：李桦[1] 苏琴[1] 刘秀兰[1] 刘学军[1] 

机构地区：[1]泰安市中心医院,泰安271000

出　　处：《现代妇产科进展》2008年第3期191-193,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨地诺前列酮栓剂(普贝生)用于足月妊娠羊水偏少病例引产的有效性和安全性。方法:随机将79例足月妊娠羊水偏少病例分为两组,分别用普贝生和缩宫素引产,比较两组的宫颈评分、临产和分娩情况、新生儿情况以及不良反应。结果:应用普贝生引产促宫颈成熟有效率高(95.74%vs 65.63%),进入产程快(10.54±5.72h vs 28.69±9.77h),产程短(5.29±2.37h vs 11.46±4.08h),阴道分娩率高(89.36%vs 46.88%),剖宫产率低(10.64%vs 53.12%),引产至出院天数缩短(4.62±1.29d vs 6.63±2.88d),对新生儿无不良影响。结论:普贝生用于足月妊娠羊水偏少病例引产安全有效,能显著提高阴道分娩率,降低剖宫产率。Objective：To explore the efficacy and safety of continuously released prostaglandin E2 （PGE2 ） suppository propess used for induction of oligohydraminios pregnancies in term. Methods：A prospective case control clinical study was carried out involved 79 cases of oligohydraminios pregnancies in term, propess was used in 47 cases and oxytocin was used in 32 cases. The rate of cervical ripening, time from induction to delivery, duration of stage, rate of vaginal delivery and Caesarean section,and side effects of drugs were compared between the two groups. Results：Compared with oxytocin, the rate of cervical ripening was higher in propess group（95.74% vs 65.63% ） ,with lower induction-delivery interval （ 10.54±5.72h vs 28.69 ±9.77h） ,shorter stage of labor（5.29 ±2.37h vs 11.46 ±4.08h） ,higher rate of vaginal delivery （89.36% vs 46.88% ） and lower rate of Caesarean section. No side effect was observed in the fetal and neonatal conditions of the two groups. Conclusion：Propess can be used for induction of pregnancy oligohydraminios pregnancies in term effectively and safely.

关 键 词：地诺前列酮 缩宫素 引产 足月妊娠 羊水过少 

分 类 号：R719.31[医药卫生—妇产科学]