糖尿病加快老年颈动脉斑块患者认知功能损害的发生  

Diabetes mellitus accelerate cognitive functional damage in older people with carotid plaque

作　　者：张涛[1] 陈阳[1] 张猛[1] 贾晓军[1] 邓娟[1] 杨珩[1] 周华东[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所神经内科,重庆400042

出　　处：《重庆医学》2008年第7期680-682,共3页Chongqing medicine

基　　金：重庆市自然科学基金计划项目(2005BB5276)

摘　　要：目的研究重庆市老年颈动脉斑块患者并发糖尿病，其认知功能损害的发生情况。方法随机抽取2005年10月～2007年10月在本科住院并进行了螺旋CT脑血管成像（CTA）或数字减影CT全脑血管造影（DSA）检查，测定有颈动脉斑块的老年患者827例。采用问卷调查的方式了解患者的既往病史，同时运用简易智能量表（MMSE）评估认知功能。测评认知功能当天清晨测量血压，空腹抽血测定血糖、糖化血红蛋白、血脂。结果827例老年颈动脉斑块患者中有糖尿病273侧（25．47％），其平均MMSE评分为21．81±1．62，明显低于无糖尿病患者，差异有统计学意义（P〈0．01）。合并糖尿病患者注意和计算能力显著低于无糖尿病组（P〈0．01）；在短程记忆、语言复述、书写、结构能力方面的分值均低，差异有统计学意义（P〈0．05）。结论糖尿病加快老年颈动脉斑块患者认知功能的损害。Objective To explore the cognitive functional damage in older people with diabetes and carotid plaque. Methods Dluster random sampling methods were used in the investigation from oct 2005 to oct 2007, Total 827 participants with examination （MMSE） was used to evaluate their cognitive function. In the morning of carotid Plaque were selected after screened with the CTA or DSA. Minl-mental state the day to examine the cognitive function,all the objects were subjected to blood pressure measurement, fasting blood glucose, glycohemoglobin and serum lipid（cholesterol, triglyceride） were analyzed by automatic biochemical analyzer. Results Among 827subjects,273 peoples（25.47%）with diabetes mellitus. Compared with no diabetes,the patients with diabetes mellitus had lower MMSE scores（ 21.8 ± 1.5）, furthermore , the scores of instant memory, attention, and language analysis also were lower. Conclusion Diabetes mellitus accelerate cognitive impairment for the patients with carotid plaque.

关 键 词：糖尿病 颈动脉斑块 认知功能 

分 类 号：R587.2[医药卫生—内分泌]