北京城区部分体检人群亚临床甲状腺功能异常发病情况调查  

Incidence of subclinical thyroid dysfunction in Beijing population by physical check-ups

作　　者：蒋秋明[1] 高燕明[1] 卢桂芝[1] 周军[1] 谢玲玎[1] 张惠敏[1] 董松[1] 彭春霞[1] 郭晓蕙[1] 高妍[1] 

机构地区：[1]北京大学第一医院内分泌科,100034

出　　处：《中华全科医师杂志》2008年第4期239-242,共4页Chinese Journal of General Practitioners

基　　金：北京大学“211工程”循证医学学科群资助项目（91000-246156057）

摘　　要：目的了解北京城区成年人群亚临床甲状腺功能异常的发病情况。方法2002年共1966人进行体检并测定血清促甲状腺激素（TSH）、甲状腺激素（T3、T4）及抗甲状腺过氧化物酶抗体（TPOAb）。2004年随访到1646人，随访率83．72％。结果亚临床甲状腺功能减退症（亚甲减）及亚临床甲状腺功能亢进症（亚甲亢）的年发病率分别为1．72％和0．25％。女性〉40岁组亚甲减年发病率高于≤40岁组，差异有统计学意义（x^2=10．869，P〈0．01），而男性两年龄组比较差异无统计学意义。〉40岁组亚甲减年发病率女性高于男性（x^2=24．122，P〈0．01），而≤40岁组男女发病率比较差异无统计学意义。亚甲亢两年龄组男女比较差异均无统计学意义。亚甲减既往史阳性组年发病率高于阴性组（x^2=6．898，P〈0．01）；家族史比较差异无统计学意义。亚甲亢既往史、家族史比较均无统计学意义。TPOAb阳性组亚甲减年发病率高于阴性组（x^2=14．084，P〈0．01）；而亚甲亢年发病率比较，差异无统计学意义。结论北京城区部分体检人群亚甲减发病率偏高，高龄、女性和TPOAb阳性者发病倾向更高。Objective To understand the incidence of subclinical thyroid dysfunction in adult population of Beijing, Methods Serum levels of thyroid-stimulating hormone （ TSH ） , T3 , T4 and thyroid peroxidase antibody （TPOAb） were measured for 1966 persons living in Beijing by physical examinations in 2002, and 1646 of them （ 83, 72% ） were followed-up in 2004, Results Overall incidence of subclinical hypothyroidism and subclinical hyperthyroidism were 1.72 percent and 0. 25 percent, respectively, Incidence of subclinical hypothyroidism in females aged 〉 40 years was significantly higher than that in those ≤40 years （x^2 = 10.869, P 〈0.01） , but no significant difference between those 〉 40 and ≤40 years in males was found, Incidence of subclinical hypothyroidism in females was significantly higher than that in males 〉 40 years of age （x^2 = 24. 122, P 〈 0.01 ） , but no significant difference between females and males≤40 years was found, No significant difference in incidence of subclinical hypothyroidism was noticed between varied age groups and between males and females, Incidence of subclinical hypothyroidism was significantly higher in those with history of subclinical hypothyroidism than that in those without it （ x^2 = 6. 898, P 〈 0. 01 ）. No significant difference in incidence of subclinical hypothyroidism between those with family history of thyroid disease and those without it was found, Incidence of subclinical hypothyroidism was significantly higher in those with positive TPOAb than that in those with negative one （ x^2 = 14.084, P 〈 0. 01 ）, but no significant difference in incidence of subclinical hyperthyroidism between those with positive and negative TPOAb was found, Conclusion Incidence of subclinical hypothyroidism was a little bit higher in population of Beijing area by physical examinations, particularly in females, elder age and positive TPOAb.

关 键 词：甲状腺疾病 发病率 横断面研究 问卷调查 

分 类 号：R5[医药卫生—内科学]