卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清IL-6的影响  

Effects of combination of captopril with lovastatin on serum IL-6 in rats with Adriamycin-induced nephropathy

作　　者：吴仁胜[1] 张道友[1] 陈忠辉[1] 杨沿浪[1] 苏惠[1] 高潮清[1] 杨利才[1] 

机构地区：[1]皖南医学院附属弋矶山医院肾内科,安徽芜湖241001

出　　处：《实用药物与临床》2008年第2期65-67,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清白介素-6(IL-6)的影响,以及两药联用保护肾脏的可能机制。方法雄性SD大鼠150只,适应性喂养2周后,随机抽取18只为正常对照组(A组),另外132只制作阿霉素肾病模型。2周末,造模成功的120只随机分为4组:B组为模型对照组(n=30);C组为卡托普利治疗组(n=30);D组为洛伐他汀治疗组(n=30);E组为两药联用组(n=30)。分别于2、4、6周末,遵循随机化原则,按n=6,分层抽取各组样本,收集实验前24 h尿液及实验时的腹动脉血,所取样本置入-20℃冰箱中保存待测。结果卡托普利与洛伐他汀联用,可进一步降低血清白介素-6及胆固醇、甘油三酯浓度,减少尿蛋白,提高血浆白蛋白浓度,其疗效优于C组、D组。结论卡托普利与洛伐他汀联用可更有效地保护阿霉素大鼠肾脏功能。Objective To investigate the effects of combination of captopril with lovastatin on serum IL-6 and its likely protective mechanism.Methods 150 male Sprague-Dawlay rats were chose.After being fed 2 weeks adaptively,18 rats were divided into normal group（A,n=18） randomly,the rest 132 for making model group.At the end of 2nd week,120 adriamycin-induced nephropathy rats were divided into four groups randomly：B for exprimental control group（n=30）,C for captopril treated group（n=30）,D for lovstatin treated group（n=30）,and E for combination of captopril with lovastatin treated group（n=30）.The rats were killed at the end of 2nd,4th,6th weekend,and the samples were stratified randomly（n=6）.The collected urine and abdominal aorta blood were reserved in refrigerator at-20 ℃ to be detected.Results Combination of captopril with lovastatin was more effective on inhibiting secretion of IL-6 of adriamycin-induced nephropathy rats,lowing IL-6,CHOL,TG and elevating albumin in serum than captopril or lovastatin.Conclusion Combination of captopril with lovastatin is more effective on protecting the kidney of adriamycin-induced nephropathy rats.

关 键 词：阿霉素肾病 白介素-6 卡托普利 洛伐他汀 

分 类 号：R96[医药卫生—药理学]