大蓟对5种癌细胞抑制作用的研究  

Study on Inhibitory Effects of Cirsium Japonicum Fisch.DC on Five Kinds of Human Carcinoma Cells

作　　者：王振飞[1] 李煜[1] 戴宝贞[1] 贾瑞贞[1] 

机构地区：[1]内蒙古大学哺乳动物生殖生物学与生物技术教育部重点实验室,内蒙古呼和浩特010021

出　　处：《中华中医药学刊》2008年第4期761-762,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30460054)

摘　　要：目的:研究大蓟对癌细胞生长的抑制作用。方法:细胞形态观察、活细胞计数法和克隆形成率法研究大蓟对人白血病细胞K562、肝癌细胞HepG2、宫颈癌细胞Hela、胃癌细胞BGC823、结肠癌细胞HT-29生长的抑制作用。结果:大蓟可使五种癌细胞形态上发生皱缩、变圆、脱壁、裂碎等变化,生长受到明显抑制,抑制率最高可达81.73%。结论:大蓟有确切的抑癌作用。Objective ：To investigate the inhibitory effects of Cirsium japonicum Fiseh. DC on growth of human carcinoma cells. Methods ：Morphological change observation,live cell accounting and cloning efficiency were used to investigate the inhibitory effects of Cirsium japonicum Fisch. DC on human chronic myloid leukemia K562 cell, hepatoma HepG2 cell, cervical carcinoma Hela cell,gastric carcinoma BGC823 cell and colonic carcinoma HT- 29 cell. Results ： Growth of the five kinds of cells was significantly inhibited by Cirsium japonicum Fisch. DC, highest inhibit rate was 81. 73% and cell morphological changes included shrinkage, roundness, floating and crumbling. Conclusion： Cirsium japonicum Fiseh. DC has reliable carcinoma - inhibiting effects.

关 键 词：大蓟 癌细胞 生长 抑制作用 

分 类 号：R285.5[医药卫生—中药学]