血清脂联素水平与2型糖尿病胰岛素抵抗的关系  

Relationship between serum adiponectin and insulin resistance in patients with type 2 diabetes mellitus

作　　者：何云[1] 崔克勤[2] 

机构地区：[1]河北工业大学医院,天津市300130 [2]河北大学附属医院内分泌科

出　　处：《河北医药》2008年第3期276-277,共2页Hebei Medical Journal

摘　　要：目的阐明脂联素与2型糖尿病胰岛素抵抗的相关性。方法2型糖尿病患者66例,根据1999年WHO诊断标准确诊,同期正常人30例年龄、性别与糖尿病足匹配。测定所有观察对象的空腹血清脂联素,体质指数、血糖、胰岛素、胰岛素抵抗指数及尿白蛋白排泄率等相关指标。用稳态模式胰岛素抵抗指数(Homa-IR)评估胰岛素抵抗。结果2型糖尿病组血清脂联素水平均低于正常对照组。Homa-IR2型糖尿病组高于正常对照组(P<0.05),脂联素水平超重肥胖者低于非肥胖者(P<0.01);相同WHR间脂联素水平2型糖尿病者较正常人低。脂联素与WHR、Homa-IR独立负相关(P<0.01)。结论血清脂联素与糖尿病、胰岛素抵抗之间存在着密切的相关性,在2型糖尿病的发生发展中发挥重要作用。Objective To clarify the effect and mechanism of serum adiponectin in the occurrence and development of type 2 diabetes mellitus. Methods According to the diagnostic standard regulated by WHO for diabetes mellitus, 66 patients were diagnosed as type 2 diabetes mellitus. There were 30 health subjects, whose age and sex were similar with those in type 2 diabetes mellitus group. Radioimmunoassay（RIA） was used to determine all the objects＇ levels of fasting serum adiponectin and to determine their relevant indexes such as body mass index（BMI）, fasting blood glocuse（FBG）, fasting blood insulin（FINS）, Homa-IR and urinary albumin excretion rate（UAER）. Results The levels of serum adiponectin in the type 2 diabetes mellitus group were significantly lower than those in control group （8.26±2.21 ug/ml VS 13.79±2.56ug/ml, P〈0.01） ; Homa-IR in type 2 diabetes mellitus group was significantly higher than that in control group （1.48 ± 0.78 VS 0.33±0.58, P〈0.01）. In the same group, the adiponectin levels in non-obesity patients were significantly higher than those patients with overweight obesity （ P 〈 0.01）. At the same WHR levels, adiponectin levels were gradually reduced in the order of NC, type 2 diabetes mellitus. Adiponectin levels were negatively correlated with WHR and Homa-IR （P〈0.01）. Conclusion There is a close relationship between serum adiponectm and insulin resistance in patients with type 2 diabetes mellitus. Serum adiponectin may play an important role in the occurrence and development of type 2 diabetes mellitus.

关 键 词：糖尿病 脂联素 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R587[医药卫生—内科学]