雷莫司琼对腹腔镜胆囊切除术后恶心及呕吐的预防作用  

The preventive effect of ramosetron on nausea and vomiting after laparoscopic cholecystectomy

作　　者：董江龙[1] 康海燕[2] 宋万军[1] 闫承勇[1] 柳顺锁[1] 殷树英[2] 

机构地区：[1]河北医科大学第三医院麻醉科,石家庄市050051 [2]河北省石家庄市第六医院六科

出　　处：《河北医药》2008年第3期293-294,共2页Hebei Medical Journal

摘　　要：目的探讨雷莫司琼对腹腔镜胆囊切除手术(laparoscopic cholecystectomy,LC)后恶心、呕吐(postoperative nausea and vomiting,PONV)的预防作用。方法选择90例ASAⅠ～Ⅱ级LC患者,随机分为3组,雷莫司琼0.3mg组(Ⅰ组)、雷莫司琼0.6mg组(Ⅱ组)、对照组(Ⅲ组),于手术结束时分别静脉注射雷莫司琼0.3mg、0.6mg和等剂量生理盐水,观察3组患者手术结束后24h内恶心及呕吐的发生情况。结果Ⅰ、Ⅱ组术后24h内恶心、呕吐发生率比Ⅲ组明显降低(P<0.05),Ⅰ、Ⅱ2组之间比较差异无统计学意义(P>0.05),3组之间药物副作用比较差异无统计学意义(P>0.05)。结论雷莫司琼是一种安全、有效、副作用小的止吐药,其临床推荐用量0.3mg即可对LC后PONV起到良好的预防作用。Objective To observe the preventive effect of ramosetron on postoperative nausea and vomiting （PONV） after laparoscopic cholecystectomy （LC）.Methods A total of 90 ASA Ⅰ-Ⅱ patients undergoing LC were randomly divided into 3 groups with 30 patients in each group. After operation, the patients in group I were given an intravenous injection of 0.3 mg ramosetron, the patients in group Ⅱ received 0.6 mg ramosetron, and the patients in group Ⅲ received isodosel normal saline. The incidence of nausea, vomiting in the 3 groups within 24h after operation was observed. Results The incidence of PONV in the group Ⅰ and Ⅱ was significantly lower than that in group Ⅲ （P〈0.05）, and there was no significant difference between group I and group Ⅱ （P〉0.05）. There was no significant differencein the incidence of side effects of ramosetron among the three groups（P〉0.05）. Conclusion Ramosetron is a safe, effective antiemetic drug with less side effects. Intravenous aministration of 0.3 mg ramosetron can produce good preventive effect on PONV after LC.

关 键 词：雷莫司琼 腹腔镜胆囊切除术 恶心 呕吐 

分 类 号：R657.4[医药卫生—外科学] R979.1[医药卫生—临床医学]