多囊卵巢综合征可能为慢性炎症性疾病  

A research on mechanisms of chronic inflammation and insulin resistance in PCOS

作　　者：夏燕[1] 郑建淮[1] 

机构地区：[1]西安交通大学医学院第一附属医院生殖医学科,陕西西安710061

出　　处：《中国妇幼健康研究》2008年第2期160-161,共2页Chinese Journal of Woman and Child Health Research

摘　　要：多囊卵巢综合征是育龄妇女生殖功能障碍、内分泌紊乱和代谢异常的常见疾患,其主要病理生理学变化是胰岛素抵抗致高雄激素血症及持续性无排卵。多囊卵巢综合征患者存在外周血促炎因子水平升高,慢性炎症介导胰岛素抵抗并进一步诱导多囊卵巢综合征的发生与发展。该文综述了慢性炎症在多囊卵巢综合征发病中的作用机制,提示多囊卵巢综合征可能一种慢性炎症性疾病,为多囊卵巢综合征的抗炎治疗提供理论依据。Polycystic ovary syndrome （PCOS） is the most common dysgenesia and endocrine dysfunction and metabolic disorder of women of childbearing age. Hyperandrogenism and chronic anovulation resulting from insulin resistance （IR） are the most important pathophysiological changes of women with PCOS, Despite of a long history of studies on PCOS, its etiology is still unknown and defined pathogenesis remains controversial. Recent studies have shown that PCOS women have a low-grade chronic inflammation, The mutual interactions of proinflammatory cytokines and IR induce occurrence and development of PCOS. This article reviewed mechanisms that proinflammatory cytokines cause IR by inhibiting different signal transduction pathways in PCOS, suggesting that PCOS may be a chronic inflammatory disease, which provides a theoretical basis for anti-inflammatory therapy for women with PCOS.

关 键 词：慢性炎症 胰岛素抵抗 多囊卵巢综合征 抗炎治疗 

分 类 号：R711.75[医药卫生—妇产科学]