肺表面活性物质治疗新生儿呼吸窘迫综合征的临床观察  

Effect of surfactant on neonatal respiratory distress syndrome

作　　者：薛良荣[1] 茅双根[1] 周名雄[1] 窦常胜[1] 李志奇[1] 郭本标[1] 

机构地区：[1]皖南医学院附属弋矶山医院 儿科,安徽芜湖241001

出　　处：《皖南医学院学报》2008年第2期108-109,共2页Journal of Wannan Medical College

摘　　要：目的:观察肺表面活性物质固尔苏治疗新生儿呼吸窘迫综合征的效果。方法:36例患儿应用周尔苏治疗,观察治疗后临床反应、血气分析的变化及疗效。结果:应用固尔苏后患儿呼吸困难、呻吟、三凹征、紫绀症状减轻或消失,辅助机械通气治疗患儿用药后30 min均下调呼吸机参数;患儿用药前后PaO_2、PaCO_2,pH比较有显著差异(P<0.001);36例患儿全治愈。结论:肺表面活性物质固尔苏治疗新生呼吸窘迫综合征的疗效较好。Objectire： To observe the effects of surfactant on neonatal respiratory distress syndrome. Methods ： 36 NRDS undergone the treatment with pulmonary surfactant were observed for clinical response, the changes of blood gas index and therapeutic effects. Results： After the administration of pulmonary surfactant, the symptoms as dyspnea, retarded expiration, three depressions sign and cynanosis were lessened and disappeared. The frequency of the assisted ventilation unit for the patients was slowed down and the difference was significant when PaO2, PaCO2 and pH were compared with pre-medication （P 〈 0. 001 ）. Conclusion ： PS can effectively improve the lung function and clinical symptom of the neonatal respiratory distress syndrome .

关 键 词：肺表面活性物质 新生儿呼吸窘迫综合征 

分 类 号：R722.12[医药卫生—儿科]