我院227株肠球菌细菌耐药性分析  

Analysis of Drug Resistance for 227 Strains Enterococci in Our Hospital

作　　者：徐旭[1] 

机构地区：[1]四川绵阳市中心医院药剂科,绵阳市621000

出　　处：《中国药房》2008年第11期834-835,共2页China Pharmacy

摘　　要：目的:了解肠球菌在临床标本中的分布及对常用抗菌药物的耐药现状。方法:对临床标本中分离出的细菌进行系统检验,采用K-B纸片法对分离鉴定后的肠球菌进行药物敏感性试验。结果:肠球菌可在临床常见的多种标本中检出,粪肠球菌(44·1%)与屎肠球菌(37·9%)常见。对常用抗菌药物的耐药性,粪肠球菌和屎肠球菌之间的差异无统计学意义。万古霉素是敏感性最高的抗菌药物。青霉素、氨苄青霉素和呋喃妥因对粪肠球菌具有较好的抗菌活性。屎肠球菌对除糖肽类以外的所有临床常用抗菌药物显示高水平耐药。结论:临床医师应关注临床常见病原菌的耐药性,动态监测肠球菌的耐药状况对指导临床治疗具有重要意义。OBJECTIVE： To study the enterococcal distribution in clinical samples and their drug resistance to commonly use antibiotic and provide the guidance for rational administration.METHODS ： Adopting paper diffusion method to observe the drug resistance of enterococci isolated from clinical samples in our hospital and analyzing their distribution in the samples.RESULTS ： Enterococcus faecalis accounts for 44.1% in 227 strains and Enterococcus faecium accounts for 37.9%, the other kinds of enterococci were rare.There was no statistical difference between drug resistance of Enterococcus faecium and that of enterococcus faecalis. Vancomycin was the most potent antimicrobial.Penicillin, ampicillin, and nitrofurantion showed good antibacterial activity against enterococcus faecalis. Enterococcus faecium displayed high level resistance against antibiotics in addition to glycopeptides.CONCLUSION： Doctor should pay attention to the drug resistance about clinically common pathogenic bacterium. Continual surveillance of resistance rate of enterococcus is important to direct the treatment of enterococcus infections.

关 键 词：肠球菌 药敏试验 耐药性 合理用药 

分 类 号：R978.1[医药卫生—药品]