疏肝健脾法对功能性消化不良胃排空及血管活性肠肽影响的临床研究  

Effect of Liver-soothing and Spleen-strengthening Therapy on Gastric Emptying and Vasoactive Intestinal Peptide in Patients with Functional Dyspepsia

作　　者：符小聪[1] 胡珂[2] 纪云西[3] 

机构地区：[1]广州中医药大学 [2]江西中医学院附属医院消化内科,江西南昌330006 [3]湖南中医药大学

出　　处：《广州中医药大学学报》2008年第2期99-102,共4页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察以疏肝健脾法为主中药对动力障碍型功能性消化不良(dysmotility-like functional dyspepsia,D-FD)患者胃排空和血管活性肠肽(vasoactive intestinal peptide,VIP)的影响。【方法】将60例D-FD患者随机分为治疗组(40例)和对照组(20例),治疗组给予疏肝健脾方(柴胡、香附、白芍、枳壳、党参、白术、法半夏、木香、鸡内金、炙甘草)加减治疗,对照组给予西药吗丁啉治疗,疗程均为4周。观察两组中医证候疗效和胃排空疗效,比较两组治疗前后空腹血浆VIP水平的变化情况,并与20例正常组做比较。【结果】在中医证候疗效方面,治疗组临床痊愈34例,显效2例,有效1例,无效3例,总有效率为92.5%;对照组临床痊愈12例,显效4例,有效2例,无效2例,总有效率为90.0%;两组比较,治疗组的中医证候总疗效与对照组相仿(P>0.05),但临床痊愈率优于对照组(P<0.05)。在胃排空疗效方面,治疗组的临床痊愈+显效(愈显)24例,有效8例,无效8例,总有效率为80.0%;对照组愈显9例,有效6例,无效5例,总有效率为75.0%;两组比较,治疗组的胃排空疗效与对照组相仿(P>0.05),但治疗组的临床愈显率优于对照组(P<0.05)。在血浆VIP水平方面,治疗前两组的VIP水平均高于正常组(P<0.05),治疗后对照组的VIP水平无明显变化,与治疗前比较,差异无显著性意义(P>0.05);治疗组的VIP水平较治疗前显著下降(P<0.05),并基本达到正常组水平(P>0.05)。【结论】疏肝健脾法为主中药可明显改善D-FD患者的胃排空功能,并可调节患者的血浆VIP水平。Objective To observe the effect of liver-soothing and spleen-strengthening therapy on gastric emptying and vasoactive intestinal peptide（VIP） in patients with dysmotility-like functional dyspepsia（D-FD）.Methods Sixty D-FD patients were randomized into two groups： group A（N=40） received Shugan Jianpi Prescription（mainly composed of Radix Bupleuri,Rhizoma Cyperi,Radix Paeoniae Alba,Fructus Aurantii,Radix Codonopsis,Rhizoma Atractylodis Macrocephalae,Rhizoma Pinelliae,Radix Aucklandiae,Endothelium Corneum Gigeriae Galli,Radix Glycyrrhizae）,and group B（N=20） received oral use of domperidone.The treatment lasted 4 weeks.The therapeutic effect on TCM syndrome and gastric emptying were evaluated after treatment.The changes of fasting plasma VIP content before and after treatment were observed in the two groups,and were compared with that in 20 healthy volunteers.Results In aspect of the therapeutic effect on TCM syndrome,34 were clinically cured in group A,2 markedly effective,1 effective,3 ineffective,and the total effective rate was 92.5%;in group B,12 were clinically cured,4 markedly effective,2 effective,2 ineffective,and the total effective rate was 90.0%;the total therapeutic effect was similar in the two groups（P〉0.05）,but the clinical cure rate in group A was higher than that in group B（P〈0.05）.As for the effect on gastric emptying,24 were clinically cured or markedly effective in group A,8 effective,8 ineffective,and the total effective rate was 80.0%;in group B,9 were clinically cured or markedly effective,6 effective,5 ineffective,and the total effective rate was 75.0%;the total therapeutic effect on gastric emptying was similar in the two groups（P〉0.05）,but the clinical cure and markedly effective rate in group A was higher than that in group B（P〈0.05）.The plasma VIP content was higher in the two groups before treatment than that in healthy volunteers（P〈0.05）.After treatment,VIP content in group B did not differ from that before treatment（P〉0.05）,but

关 键 词：消化不良/中药疗法 疏肝健脾方/治疗应用 胃排空/药物作用 血管活性肠肽/血液 

分 类 号：R259.73[医药卫生—中西医结合]