生脉胶囊对压力超负荷慢性心衰大鼠心室重构的影响  

Effect of Shengmai Capsule on Ventricular Remodeling in Rats with Chronic Congestive Heart Failure Induced by Pressure Overload

作　　者：邓元江[1] 梁伟雄[2] 张卫[3] 郑亚莉[3] 程淑意[2] 陈云波[2] 刘卫英[3] 

机构地区：[1]中山大学第一附属医院针灸科,广东广州510080 [2]广州中医药大学DME中心,广东广州510405 [3]广东药学院第一附属医院,广东广州510080

出　　处：《广州中医药大学学报》2008年第2期142-146,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：中国博士后科学基金(编号:2005038175);教育部高等学校博士学科点基金(编号:20050572008);广东省自然科学基金(编号:06300042)

摘　　要：【目的】观察生脉胶囊对压力超负荷慢性心力衰竭(CHF)大鼠心室重构的影响。【方法】SD大鼠75只,采用腹主动脉缩窄法复制大鼠慢性心力衰竭模型,设立假手术组、心衰模型组、生脉胶囊组、卡托普利组、生脉胶囊加卡托普利组,分组治疗7周时进行超声心动图检查,以左室舒张末期内径(dLVD)、室间隔舒张末期厚度(dIVST)、舒张末期容积(VED)、射血分数(pEF)、左室短轴缩短率(pFS)为指标,并计算左室质量指数(Im,LV)。【结果】模型组Im,LV、dLVD、dIVST、VED值均高于假手术组(P<0.05或P<0.01),生脉胶囊、卡托普利、生脉胶囊加卡托普利均能使其降低(P<0.05或P<0.01),且作用相同;模型组pEF、pFS均低于假手术组(P<0.01),生脉胶囊、生脉胶囊加卡托普利均能提高pEF值(P<0.01),且生脉胶囊加卡托普利的作用优于卡托普利(P<0.05);生脉胶囊、生脉胶囊加卡托普利均能提高pFS值(P<0.05或P<0.01)。【结论】生脉胶囊可改善慢性心力衰竭大鼠的心脏射血功能和心脏结构,具有抗心室重构的作用。Objective To investigate the effect of Shengmai Capsule（SC） on ventricular remodeling in rats with chronic congestive heart failure（CHF） induced by pressure overload.Methods Seventy-five SD female rats were randomlized into sham-operation group,CHF model group,SC group,captopril group and SC＋captopril group.SD rat models of CHF were induced by the method of abdominal aortic constriction.After treatment for 7 weeks,echocardiographic parameters of left ventricular end-diastolic diameter（dLVD）,end-diastolic interventricular septum thickness （dIVST）,left ventricular end-diastolic volume（dLVD）,left ventricular ejection fraction（pEF）,left ventricular fractional shortening（pFS）,and left ventricular mass index （Im,LV） were observed.Results Im,LV,dLVD,dIVST and VED in the model group were higher than those in the sham-operation group（P〈0.05 or P〈0.01）,and SC,captopril and SC＋captopril decreased the above parameters（P〈0.05 or P〈0.01）.pEF and pFS in the model group were lower than those in the sham-operation group（P〈0.01）,and SC and SC＋captopril increased pEF and pFS（P〈0.05 or P〈0.01）,SC＋captopril having a better effect on pEF than captopril only（P〈0.05）.Conclusion SC can improve the ejection fraction and heart structure in rats with CHF,and can counteract the ventricular remodeling.

关 键 词：生脉胶囊/药理学 心力衰竭 慢性/中药疗法 心室重构 超声心动图 疾病模型 动物 大鼠 

分 类 号：R285.5[医药卫生—中药学]