联合检测C-反应蛋白和IL-1β、IL-6对急性颅脑损伤预后的指导意义  

Relationship between prognosis and the dynamic change of high sensitivity C-reactive protein,IL-1β,IL-6 in acute traumatic brain injury

作　　者：斯志萍 单继烈 

机构地区：[1]浙江奉化市人民医院检验科,奉化315500

出　　处：《中国实用神经疾病杂志》2008年第4期4-6,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨颅脑损伤急性期联合检测C-反应蛋白(C-reactive protein,CRP)、白介素-1β(interleukin-1β)及白介素-6(interleukin-6)的急性变化与颅脑损伤程度和预后的关系。方法192例颅脑损伤患者依据格拉斯哥评分(Glasgow coma scale,GCS)、出院后3个月格拉斯哥预后评分(Glasgow outcome scale,GOS)依次分组,采用免疫比浊法及双抗体夹心ABC-ELISA法测定伤后24h内血清hCRPI、L-1β及IL-6的浓度。结果伤后24h内hCRPI、L-1β及IL-6升高,随着病情的好转逐渐下降,三者与GCS呈负相关(r=-0.162,P<0.05),血清hCRP与IL-1β应用直线相关分析两者呈正相关(r=0.147,P<0.05)。血清hCRP与IL-6应用直线相关分析两者呈正相关(r=0.196,P<0.01),三项检测指标之间呈直线相关。GCS不同分组检测结果组间比较,差异有统计学意义(P<0.05)。颅脑损伤急性期血清中hCRP、IL-1β及IL-6浓度在GOS评分分组后比较差异有统计学意义(P<0.01)。结论血清中hCRPI、L-1β及IL-6是颅脑损伤患者急性期脑损伤敏感而特异的指标,联合检测对判断病情及预后、早期诊治继发性脑损害有重要意义。Objective To study the relationship between dynamic change of high-sensitivity C-reactive protein （hCRP）, interleukin-l（IL-1β, interleukin-6（IL-6） in traumatic brain injury and its prognosis. Methods 192 cases patients were divided into different groups according to the Glasgow coma scale（GCS） and the Glasgow outcome scale（GOS） three months later respectively. The concentration of serum CRP ,IL-1β,IL-6 were detected with immunoturbidimetry and ABC-ELISA after traumatic brain injury in 24 hours. Results Serum hCRP levels were remarkably elevated and reached peak value within 24 hours, and then gradually decreased.There was a negative correlation between hCRP, IL-1β, IL-6 and the patients＇ GCS （r=-0. 162, P〈0.05）. There was a positive correlation between hCRP and IL- 1β（r=0. 147, P〈0.05）. There was a positive correlation between hCRP and IL-6 （r=0.196, P〈0. 01）. There were linearpositive correlations among of them. The detected consequences were significant in statistic with different GCS groups（P〈0.05）. The serum levels of hCRP,IL-1β, IL-6 in acute phase of traumatic brain were significant in statistic within different GOS groups（P〈0.01）. Conclusion The serum levels of hCRP,IL-1β,IL-6 are sensitive and specific markers in acute trau-matic brain injury. Dynamic observation on the changes is significant to judging the severity, early diagnosis and treatment of secondary brain insult and estimation of prognosis in patients with acute brain injury.

关 键 词：超敏C反应蛋白 IL-1Β IL-6 颅脑损伤 GCS评分 GOS评分 

分 类 号：R651.15[医药卫生—外科学]