他汀预处理对急性冠脉综合症患者住院期间MACCE发生率的影响  

Effect of Pre-hospital Statins Therapy on Incidence of Major Adverse Cardiac and Cerebral Events of Inpatients with ACS

作　　者：刘丽娟[1] 王强[1] 梁尹[1] 高修仁[2] 

机构地区：[1]中山大学第一附属第一医院黄埔分院心内科,广州510000 [2]中山大学第一附属第一医院心内科,广州510000

出　　处：《现代生物医学进展》2008年第3期503-504,共2页Progress in Modern Biomedicine

摘　　要：目的:探讨入院前他汀药物预处理对急性冠脉综合征患者住院期间主要心脑血管事件(MACCE)发生的影响。方法:回顾性分析2000年1月-2006年9月我院心内科急性冠脉综合症患者650例,他汀治疗组(n=350)和非他汀预处理组(n=300),采用多因素logistic回归分析他汀预处理对急性冠脉综合症患者的在住院期间的主要心脑血管事件的影响。结果:多元回归分析结果显示他汀类预处理组住院期间的死亡率和总的MACCE事件低于与非他汀预处理组,分别为0.9%(VS 1.3%)和2.9%(VS 4.8%)。结论:他汀的预处理可以减低住院期间总心血管事件和住院期间死亡率的风险,为住院期间死亡率和总MACCE事件的独立的预测因素。Objective： To investigate the effect of pre-hospital Statin therapy on the incidence of MACCE of patients with ACS during hospitalization. Methods： 650 cases of ACS in the Department of Cardiology, The Huang-pu Hospital, Sun Yat-Sen University from January, 2000 to September, 2006 was analyzed retrospectively, and the patients were divided into two groups： Statin therapy group （n=350）; Non-Statin therapy group （ n=300 ）. The effect of pre-hospital statin therapy on MACCE of patients with ACS was analyzed by Multivariate logistic regression analysis. Results： Compared with Non-Statin therapy group, the mortality and the incidence of MACCE in the Statin therapy group during hospitalization was lower, and the values were 0.9% （VS 1.3%） and 2.9% （VS 4.8% ） respectively. Conclusions： Pre-hospital Statin therapy can reduce the mortality and the incidence of MACCE of patients with ACS during hospitalization, and it was independently associated with the significant decrease in the risk of the mortality of patients with ACS during hospitalization.

关 键 词：他汀预治疗 急性冠脉综合症 主要心脑血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]