抗抑郁药吗氯贝胺的合成工艺  

The Process for Preparon of Moclobemide

作　　者：陈晶[1] 陶秀娥[1] 宋国梁 姚之庆 

机构地区：[1]河北化工医药职业技术学院,河北石家庄050026 [2]河北省化学工业研究院,河北石家庄050031

出　　处：《河北化工》2008年第4期45-46,共2页Hebei Chemical Industry

摘　　要：选择以乙醇胺为原料的合成路线,先亲核取代生成溴乙胺氢溴酸盐,再酰胺化合成中间体4-氯-N-(2-溴乙基)苯甲酰胺,最后与吗啉反应生成吗氯贝胺,产品总收率达75.0%。Moclobemide was synthesized by condensation of morpholine with 4-chloro-N- （2-bromo-ethyl） benzamide which is from the schotten-baumann reaction of 2-bromo-ethanamine hydrobromid and chloro-benzoyl chloride. This paper studied the yield of the product by altering the temperature of reaction and the proportion of materials. The novel process was evaluated and the optimum process parameters were selected. The total yield of the product is 75.0%.

关 键 词：吗氯贝胺 乙醇胺 4-氯-N-(2-溴乙基)苯甲酰胺 

分 类 号：R971.43[医药卫生—药品]