黄花石蒜抗阿尔茨海默病活性部位的筛选  

The screening of active fractions of Lycoris aurea for anti-Alzheimer′s Disease

作　　者：朱田[1] 皮慧芳[1] 张鹏[1] 阮汉利[1] 张勇慧[1] 吴继洲[1] 

机构地区：[1]华中科技大学同济药学院,湖北武汉430030

出　　处：《中国老年学杂志》2008年第7期650-651,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金项目(No30572312)

摘　　要：目的研究黄花石蒜乙醇提取物不同萃取部位对阿尔茨海默病(AD)模型小鼠学习记忆能力的影响。方法选用昆明种小鼠,皮下注射东莨菪碱(2mg/kg)制备AD小鼠模型,通过Y型水迷宫实验来观察提取物不同部位对AD模型小鼠学习记忆的影响。结果与模型组比较,黄花石蒜生物碱高剂量组(66.7g生药/kg)和低剂量组(33.3g生药/kg)均能明显缩短AD模型小鼠Y水迷宫测试的潜伏期(P<0.05),减少其上岸错误次数(P<0.05),明显改善小鼠学习记忆。结论黄花石蒜抗AD活性的有效部位是生物碱部位。Objective To screen active fractions of Lycoris aurea for anti-Alzheimer＇s disease. Methods AD model mice were made by hypodermic ：injection scopolamine. Then the mice were divided into eight groups. The mice were orally administrated with different doses of different extracts of Lycoris anrea for 50 days. The learning-memory abilities were detected on 25,50 d by Y-maze swimming testing. Results Compacted with model group,the learning-memory abilities of the mice treated with alkaloid part were better, and the delitescence to reach destination were obviously shorter （P 〈 0. 05 ）, the error times of getting to ashore were remarkably decreased （P 〈 0. 05 ）. Conclusions Alkaloid part is the effective fraction of Lycoris anrea.

关 键 词：黄花石蒜 生物碱部位 阿尔茨海默病 东莨菪碱 

分 类 号：R285.5[医药卫生—中药学]