糖尿病大鼠味腺超微结构的研究  

ULTRASTRUCTURAL STUDIES ON VON EBNER' GLAND OF DIABETES RATS

作　　者：冯晓红[1] 刘晓民[1] 周立红[1] 郑金华[2] 

机构地区：[1]哈尔滨医科大学第一临床医院内分泌科 [2]哈尔滨医科大学解剖学教研室,哈尔滨150001

出　　处：《解剖学报》2008年第2期252-254,共3页Acta Anatomica Sinica

摘　　要：目的观察2型糖尿病大鼠味腺超微结构变化。方法雄性Wistar大鼠18只,随机分为对照组和实验组,高脂喂养加小剂量链脲佐菌素(STZ)腹腔注射制备2型糖尿病模型,饲养8周后取轮廓乳头,应用透射电镜观察味腺超微结构。结果与对照组大鼠比较,实验组大鼠味腺腺泡细胞的核膜凹陷、核固缩;线粒体嵴断裂、空泡变性;粗面内质网扩张,脱颗粒。结论糖尿病可导致味腺组织出现一系列超微结构病理改变,为进一步探讨糖尿病发生机制提供了形态学依据。Objective To observe the ultrastructure changes on von Ebner＇s gland of type 2 diabetes rats. Methods Eighteen Wistar rats were randomly divided into control group and experiment group.The diabetes rats model were induced by intraperitoneal injection streptozotocin（STZ） after high-fat food.The von Ebner＇s gland ultrastructure was observed under transmission electron microscope（TEM） after 8 weeks. Results Compared with the control group,in diabetes rats acinar cell nucleus appeared nucleolemma introcession and karyopycnosis;mitochondria exhibited vacuole degeneration and crista breaking;rough endoplasmic reticula expanded and showed degranulation.Conclusion A sereies of pathologic changes in von Ebner＇s gland of diabetes rats can be induced by diabetes,which provides morphological evidences for further investigation on the mechanism of diabetes complication.

关 键 词：糖尿病 味腺 超微结构 透射电镜 大鼠 

分 类 号：R322.41[医药卫生—人体解剖和组织胚胎学]