色素上皮衍生因子和血管上皮生长因子在良性前列腺增生组织中的表达及意义  

Expression of pigment epithelium-derived factor and vascular endothelial growth factor in benign prostatic hyperplasia

作　　者：胡卫国[1] 卢洪凯[1] 刘鲁东[1] 臧运江[1] 王沈阳[1] 张明荣[1] 

机构地区：[1]山东省潍坊市人民医院泌尿外科,山东潍坊261041

出　　处：《临床泌尿外科杂志》2008年第2期135-137,共3页Journal of Clinical Urology

基　　金：山东省卫生厅青年基金资助(编号:2005JW034)

摘　　要：目的:探讨色素上皮衍生因子(PEDF)和血管上皮生长因子(VEGF)在BPH组织中的表达特点和意义。方法:对35例手术切除的BPH组织(BPH组),21例正常前列腺组织(对照组)行免疫组织化学法检测PEDF和VEGF的表达水平和微血管密度(MVD)计数,统计学分析两组标本表达水平的差异以及各因素之间的相关性。结果:BPH组中VEGF和MVD表达明显高于对照组(P<0.01),PEDF表达明显低于对照组(P<0.01);MVD与VEGF表达呈显著正相关(P<0.05),与PEDF表达呈显著负相关(P<0.05);VEGF与PEDF表达呈显著负相关(P<0.01)。结论:PEDF表达水平降低和VEGF表达水平增加,促进前列腺组织的血管生成作用,导致前列腺组织增生。PEDF和VEGF的不平衡表达可能是BPH组织血管生成的分子基础,是促进BPH发生和发展的因素。Objective：To study the expression of vascular endothelial growth factor （VEGF） and pigment epithelium-derived factor （PEDF） in benign prostatic hyperplasia and explore the possible role of these factors in the process of neovascular formation. Methods：Immunohistochemistry was used to detect the expression of VEGF and PEDF in 35 surgical specimens of BPH from patients and 21 normal prostatic tissue from donors. CD34 immunohistochemical staining was used to measure the microvessel density （MVD） so as to investigate the microvessel forming status. The association of these two factors with MVD were analyzed. Results：The expression of PEDF in BPH were lower than that in normal prostate, but VEGF level in BPH were higher than that in normal prostate. MVD positive expression has a positive relationship with VEGF, but a negative relationship with PEDF expression. Furthermore, there was a negative correlation between VEGF and PEDF expression. Conclusions： VEGF and PEDF are expressed in BPH. They are antagonistic to each other in the process of neovessels forming. The unbalance expression of VEGF and PEDF may play a role in the formation and progression of BPH.

关 键 词：良性前列腺增生 色素上皮衍生因子 血管上皮生长因子 血管生成 

分 类 号：R697[医药卫生—泌尿科学]