萘普生微乳的制备及其体外透皮吸收的研究  

Study on preparation of naproxen microemulsion and its transdermal absorption

作　　者：李先红[1] 崔萍 刘榛榛[1] 

机构地区：[1]襄樊学院化学与生物科学系,湖北襄樊441053

出　　处：《中国医院药学杂志》2008年第7期508-511,共4页Chinese Journal of Hospital Pharmacy

基　　金：湖北省教育厅重点科研项目(编号:2001A69005)

摘　　要：目的:制备高稳定性的萘普生微乳,考察萘普生微乳对离体小鼠皮的透皮能力。方法:通过原子力扫描探针显微镜、ζ-电位粒度仪测定萘普生微乳的粒度及其分布。用稳定性实验考察萘普生微乳的稳定性。用改进的Franz扩散池研究萘普生微乳的透皮速率。高效液相色谱法测定萘普生的含量。结果:1%萘普生的微乳液滴的平均粒径为(48.6±1.8)nm,萘普生的平均透皮速率为(115.06±9.87)μg.cm-2.h-1,透皮吸收行为符合Fick′s第一定律。结论:萘普生微乳能够显著促进萘普生的透皮吸收。OBJECTIVE To prepare O/W microemulsion formulasion containing naproxen and investigate its in vitro transdermal delivery ability. METHODS The mieroemulsion was prepared and characterized using atomic force microscope and zetasizer analysis instrument. The permeation flux of naproxen was determined in vitro using Franz diffusion cell. The content of naproxen was measured by HPLC. The stability tests were performed to evaluate thenaproxen microemulsiolL RESULTS The average droplet size of microemulsion containing 1% naproxen was （48.6±1.8）nm. The permeation rate of （115.06±9. 87）μg·cm^-2·h^-1 was showed in vitro. The permeation of the microemulsion was described by the Fick＇s frist diffustion law. CONCLUSION These results indicates that the studied miroemulsion system could improve the transdermal absorption of naproxen.

关 键 词：微乳 萘普生 制备 透皮吸收 

分 类 号：R978.1[医药卫生—药品]