158例癫痫患儿血清卡马西平浓度监测  

Analysis of drug monitoring of carbamazepine serum concentration of 158 epileptic children

作　　者：田应彪[1] 陈泽慧[2] 汪世明[1] 程昌华[1] 王敏[1] 何勇[1] 王承建[1] 

机构地区：[1]遵义医学院附属医院药剂科,贵州遵义563003 [2]遵义医学院附属医院检验科,贵州遵义563003

出　　处：《中国医院药学杂志》2008年第7期563-565,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:通过监测癫痫患儿血清卡马西平(CBZ)浓度,探讨影响其浓度的因素,为临床制定个体化给药方案提供依据。方法:采用荧光偏振免疫法(FPIA)测定癫痫儿童血清CBZ浓度,并结合临床疗效进行分析。结果:158例癫痫儿童血清CBZ质量浓度小于4mg·L-1有28例,其中控制+有效为11例(39.3%);大于12mg·L-1有8例,其中1例无效(12.5%);在4～12mg·L-1有122例,控制+有效为110例(90.2%)。结论:癫痫患儿血清CBZ浓度受年龄、个体差异、药物相互作用等因素的影响,常规监测其浓度,对确保安全、有效、合理使用抗癫痫药物具有十分重要的意义。OBJECTIVE To minitore the serum concentration of carbamazepine of epileptic children to study the influencing factors and for the individual medication. METHODS The serum concentration was measured using FPIA, the results were analysed according to the clinical efficacy. RESULTS Serum cencentration of 28 cases was less than 4 mg·L^-1, among them 11 cases were controllable and effective （39.3）, 8 cases were more than 12 mg·L^-1 and one case was not effective （12. 5%）, the concentration of 122 cases was 4-12 mg·L^-1,110 cases were controllable and effective （90.2%）. CONCLUSION The serum concentration is influenced by the age, individual deference, drug interaction and other factors. The monitoring of the concentration is useful for the safe and effective use of the anti epileptic drugs.

关 键 词：卡马西平 血清浓度 癫痫患儿 个体化给药 

分 类 号：R969[医药卫生—药理学]