影响双氯芬酸钾口腔粘附片的粘附性和体外释药的因素考察  

Effects of Formulation on Adhesive Characteristics and Release Rate of Diclofenac Potassium Buccal Adhesive Tablet in vitro

作　　者：符旭东[1] 郭家平[1] 覃贝[1] 

机构地区：[1]广州军区武汉总医院药剂科,武汉430070

出　　处：《中国药师》2008年第4期383-385,共3页China Pharmacist

摘　　要：目的:考察处方对双氯芬酸钾口腔粘附片(DP)体外释药和粘附性的影响。方法:以羟丙甲基纤维素(HPMC)、卡波姆(Carbopol)、甘露醇为辅料制备DP。采用改进的转篮法测定DP的体外释放度,通过粘附时间和粘附力评价DP的粘附性。结果:当HPMC和Carbopol在处方中的比例为25%,Carbopol和HPMC的比例为1:4时,粘附时间为405 min,粘附力为16.9 g,体外释药曲线(0～180 min)符合Higuchi方程(F=8.0331,r=0.9909)。结论:双氯芬酸钾口腔粘附片具有良好粘附性,能快速起效并持续释药3 h。Objective： To investigate the effects of formulation on adhensive characteristics and release rate of diclofenac potassium buccal adhensive tablets in vitro, Method： Carbopol, HPMC and mannitol were used to fabricate buccal adhensive tablets, The release rate was determined by modified rotating basket method in vitro. Adhensive characteristics was evaluated by adhensive time and adhensive force. Result： The optimal formulation was as followed： the amount weight percentage of Carbopol and HPMC was 25%, the weight ratio of Carbopol to HPMC was 1：4. The adhesive time was 405 min and the adhensive force was 16.9 g. The release profiles conformed to Higuchi equation in vitro （F = 8,0331, r = 0. 990 9）, Conclusion. Diclofenac potassium buccal adhensive tablet had good adhesive characteristics and could exert effects quickly and sustained release for more than 3 hours,

关 键 词：双氯芬酸钾 口腔粘附片 粘附力 粘附时间 体外释放度 

分 类 号：R945[医药卫生—微生物与生化药学]