联苯双酯固体脂质纳米粒的制备  

Preparation of bifendate-loaded solid lipid nanoparticles

作　　者：张洪[1] 詹新安[2] 成蓓[2] 谭晔[2] 

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060 [2]武汉大学药学院,湖北武汉430072

出　　处：《广东药学院学报》2008年第1期37-40,50,共5页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的以乳化蒸发—低温固化法制备联苯双酯固体脂质纳米粒。方法在单因素考察的基础上以正交试验优化、筛选最佳处方和制备工艺。用透射电镜观察固体脂质纳米粒的形态,激光粒度仪测定Zeta电位和粒径大小,葡聚糖凝胶柱法测定其包封率。结果所制得的联苯双酯固体脂质纳米粒外观形态圆整,粒度分布均匀,平均粒径为(193±6)nm,电位为(-21.5±1.2)mV,包封率为(45.1±1.1)%。结论乳化蒸发—低温固化法适用于联苯双酯固体脂质纳米粒的制备。Objective To prepare bifendate-loaded solid lipid nanoparticles by emulsification-evaporation. Methods Based on the result of single factor experiments, four factors affecting the formulation were optimized by orthogonal design. The diameters and the Zeta potentials were measured. TEM was used to observe the particle shapes, and the encapsulation rate was determined by Sephadex gel chromatography. Results The mean particle size was found to be 193 ＋ 6 nm with a narrow particles distribution of polydispersity index. The ＂Zeta potential of the optimized bifendate-loaded solid lipid nanoparticles was （ -21.5 ± 1.2） mV, and the drug entrapment efficiency was （45.1 ± 1.1 ） %. Conclusion The method of emulsification-evaporation was appropriate for the preparation of bifendateloaded solid lipid nanoparticles.

关 键 词：联苯双酯 固体脂质纳米粒 乳化蒸发-低温固化法 

分 类 号：R94[医药卫生—药剂学]