总丹酚酸滴丸的成型工艺研究  

Study on moulding technics of total salvianolic acid dripping pills

作　　者：熊红仔 刘昀[2] 伍振峰[3] 赵冰洁[3] 

机构地区：[1]广州美晨药业有限公司生产技术部,广东广州510075 [2]广州医学院第二附属医院,广东广州510260 [3]广东药学院,广东广州510006

出　　处：《广东药学院学报》2008年第1期44-46,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的将从丹参提取液中分离纯化得到的总丹酚酸制成滴丸,并优选其成型工艺。方法采用正交试验法,以滴丸的丸重差异、溶散时限、圆整度为评价指标,优选滴丸成型的药液温度、滴头内径、滴距、滴速的工艺条件。结果最佳工艺条件为:药液温度90℃,滴头内径4.5 mm,滴距6 cm,滴速50滴/min。结论确立的成型工艺可行,所制滴丸符合质量标准。Objective To establish an optimum preparation process for total salvianolic acid dripping pills. Methods Orthogonal design was performed to select the temperature of drug, inteinal diameter of burette, dripping distance and dripping speed. The weight variation, resolving time and grain roundness were used as criteria in the best dripping condition. Results The optimum dripping condition was as the follows ： the temperature was 90℃, the internal diameter of burette was 4.5 mm, dripping speed was 50 drops per minute, and dripping distance was 6 cm. Conclusion The moulding technics are feasible and in accordance with the quality standards of total salvianolic acid dripping pills.

关 键 词：总丹酚酸 成型工艺 正交试验 

分 类 号：TQ461[化学工程—制药化工]